Pathology and pathophysiology of pneumoconiosis.
Pathology and pathophysiology of pneumoconiosis.
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DOI：
10.1097/00063198-200003000-00010
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发表时间：
2000-03-01
影响因子：
3.3
通讯作者：
Fujimura, N
中科院分区：
文献类型：
--
作者：
Fujimura, N
硅肺和石棉肺的细胞和分子机制以及相关基因的表达已被广泛研究，参与启动炎症和纤维化进展的复合机制也被广泛研究，但尚未完全了解。本文综述了近年来这一领域的研究进展，特别是关于这些尘肺病的病理生理学。矽肺和石棉肺是尘肺的两种主要类型。尽管矽肺和石棉肺的临床病理特征明显不同，但它们都是由于长期接触空气中的无机粉尘而引起的间质性肺疾病，其病理本质是纤维化。
Cellular and molecular mechanisms, as well as associated gene expressions, in silicosis and asbestosis are widely investigated, and compound mechanisms involved in initiating inflammation and progression to fibrosis are comprehensively studied, though not yet totally understood. Recent advances in this field, especially concerning pathophysiology of these pneumoconioses, are reviewed in this article. Silicosis and asbestosis are two major types of pneumoconiosis. Although the clinico-pathologic features presented are apparently different, silicosis and asbestosis are both interstitial lung diseases caused by chronic exposure to airborne inorganic dusts, and the pathology of these two diseases is essentially a fibrosis.