Risks of all-cause and suicide mortality in mental disorders: a meta-review
Risks of all-cause and suicide mortality in mental disorders: a meta-review
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DOI：
10.1002/wps.20128
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发表时间：
2014-06-01
期刊：
影响因子：
73.3
通讯作者：
Fazel, Seena
中科院分区：
文献类型：
--
作者：
Chesney, Edward;Goodwin, Guy M.;Fazel, Seena
进行了一项荟萃综述或系统综述综述，以探讨主要精神障碍的全因死亡率和自杀死亡率的风险。一项系统性检索产生了407篇相关综述，其中20篇报道了20种不同精神障碍的死亡风险，包括170多万患者和25多万例死亡。与一般人群相比，所有疾病的全因死亡风险都有所增加，许多疾病的死亡风险大于或相当于重度吸烟。全因死亡率最高的是药物使用障碍和神经性厌食症。这些更高的死亡风险转化为预期寿命的大幅减少（10-20年）。边缘型人格障碍、神经性厌食症、抑郁症和双相情感障碍的自杀风险最高。在综述文献中发现了显著的差距，纳入的综述质量通常较低。所有精神疾病的死亡率和自杀的过度风险证明了对精神病患者过早死亡的决定因素的研究，预防和治疗的更高优先级。
A meta-review, or review of systematic reviews, was conducted to explore the risks of all-cause and suicide mortality in major mental disorders. A systematic search generated 407 relevant reviews, of which 20 reported mortality risks in 20 different mental disorders and included over 1.7 million patients and over a quarter of a million deaths. All disorders had an increased risk of all-cause mortality compared with the general population, and many had mortality risks larger than or comparable to heavy smoking. Those with the highest all-cause mortality ratios were substance use disorders and anorexia nervosa. These higher mortality risks translate into substantial (10-20 years) reductions in life expectancy. Borderline personality disorder, anorexia nervosa, depression and bipolar disorder had the highest suicide risks. Notable gaps were identified in the review literature, and the quality of the included reviews was typically low. The excess risks of mortality and suicide in all mental disorders justify a higher priority for the research, prevention, and treatment of the determinants of premature death in psychiatric patients.