Anabolic-androgenic steroids: effects on social behavior and baseline heart rate.
Anabolic-androgenic steroids: effects on social behavior and baseline heart rate.
复制标题
合成代谢雄激素类固醇：对社会行为和基线心率的影响。
DOI：
10.1037//0278-6133.9.6.774
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Manuck,SB
中科院分区：
文献类型：
--
作者：
Rejeski,WJ;Gregg,E;Kaplan,JR;Manuck,SB
研究了合成代谢-雄激素(AS)对行为、基线心率(HR)和应激诱导的HR反应的影响。24只食蟹猴被分配到AS和假对照组的四个混合社会群体中。在两个月的时间里，接受AS治疗的猴子每两周注射一次睾酮，并按照相同的程序给对照动物注射假溶液。行为数据显示，AS扰乱了社会环境，使所有优势动物的优势行为增加，从属动物表现出更多的顺从。这些变化在药物干预结束8周后恢复到试验前水平。作为AS的一种功能，所有动物的附属行为都减少了，并且在8周的恢复期后，除了游戏行为外，未能恢复到测试前的水平。AS导致基线心率增加，特别是在优势动物中。有趣的是，作为动物的从属动物经历了基线HR反应的减少。AS对应激诱导的HR反应性无明显影响。
Examined the effects of anabolic-androgenic steroids (AS) on behavior, baseline heart rate (HR), and stress-induced HR responses. Twenty-four cynomolgus monkeys were assigned to four mixed social groups of both AS and sham control animals. For 2 months, AS-treated monkeys received biweekly injections of testosterone, and, on an identical schedule, the control animals were injected with a sham solution. Behavioral data revealed that AS disrupted the social milieu such that all dominant animals exhibited increases in dominant behavior and subordinates manifested increased submission. These changes returned to pretest levels 8 weeks following termination of the drug intervention. Affiliative behaviors decreased on the part of all animals as a function of AS and, with the exception of play behavior, failed to return to pretest levels after the 8-week period of recovery. AS created an increase in baseline HR, particularly among the dominant animals. Interestingly, the subordinate AS animals experienced a decrease in baseline HR response. AS had no apparent influence on stress-induced HR reactivity.