Modular approach for modeling cell motility
Modular approach for modeling cell motility
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DOI：
10.1140/epjst/e2014-02190-2
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发表时间：
2014-06-01
影响因子：
2.8
通讯作者：
Aranson, I. S.
中科院分区：
文献类型：
--
作者：
Ziebert, F.;Aranson, I. S.
细胞运动建模是一项具有挑战性的任务，因为运动机制是高度复杂的。此外，不同的细胞类型有相当广泛的多样性。为了深入了解几种不同细胞类型的运动机制的一般特征，我们提出了一种模块化方法，该方法从最小模型开始，由移动细胞边界的相场描述和简化的内部动力学组成。我们将讨论如何扩展这个起点以提高细节水平，以及如何更改/调整内部动态“模块”以正确模拟各种细胞类型。前者允许在自组织运动结构域的框架内研究细胞运动的特定过程，后者可能允许将不同的细胞运动机制纳入一个统一的框架。
Modeling cell movement is a challenging task since the motility machinery is highly complex. Moreover, there is a rather broad diversity of different cell types. In order to obtain insights into generic features of the motility mechanisms of several distinct cell types, we propose a modular approach that starts with a minimal model, consisting of a phase field description of the moving cell boundary and a simplified internal dynamics. We discuss how this starting point can be extended to increase the level of detail, and how the internal dynamics "module" can be changed/adjusted to properly model various cell types. The former route allows studying specific processes involved in cell motility in the framework of a self-organized moving domain, and the latter might permit to put different cellular motility mechanisms into a unified framework.