Nephrotic syndrome-induced thromboembolism in adults.
Nephrotic syndrome-induced thromboembolism in adults.
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DOI：
10.4103/2229-5151.183019
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发表时间：
2016-04
影响因子：
--
通讯作者：
Song M
中科院分区：
文献类型：
--
作者：
Al-Azzawi HF;Obi OC;Safi J;Song M
肾病综合征（NS）是一种明确定义的综合征，其特征在于存在肾病范围的蛋白尿、低白蛋白血症和高脂血症。尽管静脉血栓栓塞（VTE）是NS相关的一种已被广泛报道的并发症，但其发病率、患病率、风险因素、治疗选择和预防策略尚未得到充分确定。肾病患者的血栓栓塞现象被假定为受影响的肾脏的抗血栓形成因子的尿损失和肝脏的促血栓形成因子的产生增加的结果。文献中报告的大多数与NS相关的VTE病例均具有已知的NS诊断。我们报告一例年轻女性表现为呼吸困难和肺栓塞。她被发现患有NS和右肾静脉血栓形成。我们回顾了现有的文献，以强调临床医生治疗NS患者VTE的最佳方法。
Nephrotic syndrome (NS) is a well-defined syndrome characterized by the presence of nephrotic range of proteinuria, hypoalbuminemia, and hyperlipidemia. Although venous thromboembolism (VTE) is a well-reported complication associated with NS, the incidence, prevalence, risk factors, treatment options, and preventative strategies are not well-established. Thromboembolic phenomena in nephrotic patients are postulated to be a result of the urinary loss of antithrombotic factors by affected kidneys and increased production of prothrombotic factors by the liver. Most cases of VTE associated with NS reported in the literature have a known diagnosis of NS. We report a case of a young female presenting with dyspnea and a pulmonary embolism. She was found to have NS and right renal vein thrombosis. We review the available literature to highlight the best approach for clinicians treating VTE in patients with NS.