MEASUREMENT OF LUNG EXPANSION WITH COMPUTED-TOMOGRAPHY AND COMPARISON WITH QUANTITATIVE HISTOLOGY
MEASUREMENT OF LUNG EXPANSION WITH COMPUTED-TOMOGRAPHY AND COMPARISON WITH QUANTITATIVE HISTOLOGY
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DOI：
10.1152/jappl.1995.79.5.1525
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发表时间：
1995-11-01
影响因子：
3.3
通讯作者：
HOGG, JC
中科院分区：
文献类型：
--
作者：
COXSON, HO;MAYO, JR;HOGG, JC
通过计算机断层扫描（CT）估计总肺体积和局部肺体积，并通过使用根据肺的X射线衰减值和压力-体积曲线估计的每克组织的气体毫升数来确定胸膜压力梯度。数据显示，CT准确估计了切除肺叶的体积，但高估了其重量24 +/-19%。在重力依赖性区域，每克组织的气体体积较少，这是由于胸腔内下降的胸膜压力梯度为0.24 +/- 0.08 cmH（2）O/cm。CT获得的组织与空气的比例与定量组织学获得的相似。我们的结论是，CT扫描可用于估计总的和区域的肺容量和测量的组织和空气的比例，胸部内的CT可用于与定量组织学，以评估肺结构。
The total and regional lung volumes were estimated from computed tomography (CT), and the pleural pressure gradient was determined by using the milliliters of gas per gram of tissue estimated from the X-ray attenuation values and the pressure-volume curve of the lung. The data show that CT accurately estimated the volume of the resected lobe but overestimated its weight by 24 +/- 19%. The volume of gas per gram of tissue was less in the gravity-dependent regions due to a pleural pressure gradient of 0.24 +/- 0.08 cmH(2)O/cm of descent in the thorax. The proportion of tissue to air obtained with CT was similar to that obtained by quantitative histology. We conclude that the CT scan can be used to estimate total and regional lung volumes and that measurements of the proportions of tissue and air within the thorax by CT can be used in conjunction with quantitative histology to evaluate lung structure.