TBX2 expression is regulated by PAX3 in the melanocyte lineage.
TBX2 expression is regulated by PAX3 in the melanocyte lineage.
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DOI：
10.1111/pcmr.12029
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发表时间：
2013-01
影响因子：
4.3
通讯作者：
Cui R
中科院分区：
文献类型：
--
作者：
Liu F;Cao J;Lv J;Dong L;Pier E;Xu GX;Wang RA;Xu Z;Goding C;Cui R
配对盒同源异型基因 3 (PAX3) 是维持黑素细胞祖细胞的关键调节因子，但在黑色素瘤中的作用尚不明确。为了了解 PAX3 如何影响黑色素细胞和黑色素瘤增殖，我们通过基因表达谱鉴定了潜在的 PAX3 下游靶标。在这里，我们将 TBX2（细胞身份的关键发育调节因子和黑色素瘤中的抗衰老因子）确定为直接调节的 PAX3 靶标。我们还发现TBX2参与黑色素瘤细胞的存活，并且在一些黑色素瘤标本中过度表达。将 TBX2 确定为 PAX3 的靶标，为了解 PAX3 如何促进黑色素瘤进化提供了关键见解，并可能为旨在破坏 PAX3 调节 TBX2 能力的促衰老治疗干预提供机会。
The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here we identify TBX2, a key developmental regulator of cell identity and an anti-senescence factor in melanoma, as a directly regulated PAX3 target. We also found that TBX2 is involved in the survival of melanoma cells, and is overexpressed in some melanoma specimens. The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution and may provide opportunities for pro-senescence therapeutic intervention aimed at disrupting the ability of PAX3 to regulate TBX2.