Molecular Mechanisms That Contribute to Bone Marrow Pain.
Molecular Mechanisms That Contribute to Bone Marrow Pain.
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DOI：
10.3389/fneur.2017.00458
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发表时间：
2017
影响因子：
3.4
通讯作者：
Ivanusic JJ
中科院分区：
文献类型：
--
作者：
Ivanusic JJ
与骨骼病理学相关的疼痛给个人、社会和全世界的卫生保健系统带来了重大负担。涉及骨髓的病理激活外周骨髓伤害感受器的感觉神经末梢，并且是疼痛的可能触发器。这篇综述介绍了我们目前对骨髓伤害性感受器如何受到与骨髓相关的病理学中的伤害性刺激的影响的理解。许多离子通道和受体正在成为外周骨髓伤害感受器活性的重要调节剂。神经生长因子（NGF）隔离已被用于治疗炎性骨痛（骨关节炎），并且有明显的证据表明NGF与骨髓伤害感受器相互作用。瞬时受体电位阳离子通道亚家族V成员1的激活使骨髓伤害感受器敏感，并可能导致各种骨病理中患者对伤害性刺激的敏感性增加。酸感应离子通道感应骨髓微环境中组织pH值的变化，可以有针对性地治疗涉及骨髓酸中毒的病理。Piezo2是一种机械门控离子通道，最近报道其由大多数有髓骨髓伤害感受器表达，并且可能是针对机械诱导的骨痛的治疗靶点。这些离子通道和受体可能是开发外周作用药物以治疗骨源性疼痛的有用靶点。
Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone marrow activates sensory nerve terminal endings of peripheral bone marrow nociceptors, and is the likely trigger for pain. This review presents our current understanding of how bone marrow nociceptors are influenced by noxious stimuli presented in pathology associated with bone marrow. A number of ion channels and receptors are emerging as important modulators of the activity of peripheral bone marrow nociceptors. Nerve growth factor (NGF) sequestration has been trialed for the management of inflammatory bone pain (osteoarthritis), and there is significant evidence for interaction of NGF with bone marrow nociceptors. Activation of transient receptor potential cation channel subfamily V member 1 sensitizes bone marrow nociceptors and could contribute to increased sensitivity of patients to noxious stimuli in various bony pathologies. Acid-sensing ion channels sense changes to tissue pH in the bone marrow microenvironment and could be targeted to treat pathology that involves acidosis of the bone marrow. Piezo2 is a mechanically gated ion channel that has recently been reported to be expressed by most myelinated bone marrow nociceptors and might be a target for treatments directed against mechanically induced bone pain. These ion channels and receptors could be useful targets for the development of peripherally acting drugs to treat pain of bony origin.
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影响因子：
3.3
作者：
Castañeda-Corral G;Jimenez-Andrade JM;Bloom AP;Taylor RN;Mantyh WG;Kaczmarska MJ;Ghilardi JR;Mantyh PW
通讯作者：
Mantyh PW
DOI：
10.1073/pnas.1221400110
发表时间：
2013-03-19
影响因子：
11.1
作者：
Coste, Bertrand;Houge, Gunnar;Patapoutian, Ardem
通讯作者：
Patapoutian, Ardem
影响因子：
2.9
作者：
Alamri, Abdulhakeem;Bron, Romke;Ivanusic, Jason J.
通讯作者：
Ivanusic, Jason J.
影响因子：
64.8
作者：
Coste, Bertrand;Xiao, Bailong;Santos, Jose S.;Syeda, Ruhma;Grandl, Joerg;Spencer, Kathryn S.;Kim, Sung Eun;Schmidt, Manuela;Mathur, Jayanti;Dubin, Adrienne E.;Montal, Mauricio;Patapoutian, Ardem
通讯作者：
Patapoutian, Ardem
影响因子：
5.3
作者：
Cain, DM;Wacnik, PW;Simone, DA
通讯作者：
Simone, DA