Immunoglobulin heavy-chain enhancer requires one or more tissue-specific factors.
Immunoglobulin heavy-chain enhancer requires one or more tissue-specific factors.
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免疫球蛋白重链增强剂需要一种或多种组织特异性因子。
DOI：
10.1126/science.3917575
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Calame,K
中科院分区：
文献类型：
--
作者：
Mercola,M;Goverman,J;Mirell,C;Calame,K
增强子序列是大大增加某些真核基因转录的调控区域。在b细胞成熟早期，免疫球蛋白重链可变基因片段从缺乏增强子活性的区域移动到已知重链增强子附近的位置。在淋巴样细胞中，重链和SV40增强子结合对增强子功能至关重要的共同因子。相反，成纤维细胞含有一种功能独特的因子，该因子被SV40使用，而不被重链增强子使用。这些细胞中不同因子的存在可能解释了先前描述的重链增强子的淋巴样细胞特异性。
Enhancer sequences are regulatory regions that greatly increase transcription of certain eukaryotic genes. An immunoglobulin heavy-chain variable gene segment is moved from a region lacking enhancer activity to a position adjacent to the known heavy-chain enhancer early in B-cell maturation. In lymphoid cells, the heavy-chain and SV40 enhancers bind a common factor essential for enhancer function. In contrast, fibroblast cells contain a functionally distinct factor that is used by the SV40 but not by the heavy-chain enhancer. The existence of different factors in these cells may explain the previously described lymphoid cell specificity of the heavy-chain enhancer.