Metastamir: the field of metastasis-regulatory microRNA is spreading.
Metastamir: the field of metastasis-regulatory microRNA is spreading.
复制标题
DOI：
10.1158/0008-5472.can-09-2111
复制
发表时间：
2009-10-01
期刊：
影响因子：
11.2
通讯作者：
Welch DR
中科院分区：
文献类型：
--
作者：
Hurst DR;Edmonds MD;Welch DR
尽管世纪来转移研究的知识有所进步，但癌症转移所需的遗传程序和分子机制仍不完全清楚。特异性调节转移过程的基因是阐明分子机制的有用工具，并且可能成为抗转移治疗的标志物和/或靶标。最近，一些非编码调控RNA基因，microRNA（miRNA），被确定在转移的各个步骤中发挥作用，一些在肿瘤发生中没有明显的作用。了解这些转移相关的miRNA（我们称之为metastamir）如何参与转移，将有助于确定癌症最致命属性-转移的可能生物标志物或靶标。
Despite advancements in knowledge from over a century of metastasis research, the genetic programs and molecular mechanisms required for cancer metastasis are still incompletely understood. Genes that specifically regulate the process of metastasis are useful tools to elucidate molecular mechanisms and may become markers and/or targets for anti-metastatic therapy. Recently, several non-coding regulatory RNA genes, microRNA (miRNA), were identified that play roles in various steps of metastasis, some without obvious roles in tumorigenesis. Understanding how these metastasis-associated miRNA, which we term metastamir, are involved in metastasis will help identify possible biomarkers or targets for the most lethal attribute of cancer - metastasis.