Early- and Late-Born Parvalbumin Basket Cell Subpopulations Exhibiting Distinct Regulation and Roles in Learning
Early- and Late-Born Parvalbumin Basket Cell Subpopulations Exhibiting Distinct Regulation and Roles in Learning
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DOI：
10.1016/j.neuron.2015.01.011
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发表时间：
2015-02-18
期刊：
影响因子：
16.2
通讯作者：
Caroni, Pico
中科院分区：
文献类型：
--
作者：
Donato, Flavio;Chowdhury, Ananya;Caroni, Pico
大脑网络可以通过促进任务相关信息的获取或遵守有效规则来支持学习，但所涉及的机制知之甚少。在学习时，局部抑制性小白蛋白（PV）表达的篮状细胞网络可以切换到相反的配置，要么有利于或干扰进一步的学习，但这种相反的可塑性是如何诱导的，并与不同的学习要求仍不清楚。在这里，我们表明，PV篮细胞由迄今未被识别的亚群，具有不同的神经发生，输入连接，输出目标神经元，和学习中的作用。海马早生PV神经元的可塑性在规则巩固中被招募，而晚生PV神经元的可塑性在新信息获取中被招募。这涉及到通过兴奋来调节早期出生的神经元可塑性，以及通过抑制来调节晚期出生的神经元可塑性。因此，相反的学习要求是通过不同的局部网络实现的，这些网络涉及通过抑制或兴奋特异性调节的PV篮细胞亚群。
Brain networks can support learning by promoting acquisition of task-relevant information or by adhering to validated rules, but the mechanisms involved are poorly understood. Upon learning, local inhibitory parvalbumin (PV)-expressing Basket cell networks can switch to opposite configurations that either favor or interfere with further learning, but how this opposite plasticity is induced and relates to distinct learning requirements has remained unclear. Here, we show that PV Basket cells consist of hitherto unrecognized subpopulations, with distinct schedules of neurogenesis, input connectivities, output target neurons, and roles in learning. Plasticity of hippocampal early-born PV neurons was recruited in rule consolidation, whereas plasticity of late-born PV neurons was recruited in new information acquisition. This involved regulation of early-born neuron plasticity specifically through excitation, and of late-born neuron plasticity specifically through inhibition. Therefore, opposite learning requirements are implemented by distinct local networks involving PV Basket cell subpopulations specifically regulated through inhibition or excitation.