Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin
Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin
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DOI：
10.1016/j.phymed.2007.01.005
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发表时间：
2007-11-01
期刊：
影响因子：
7.9
通讯作者：
Milillo, Maria Antonietta
中科院分区：
文献类型：
--
作者：
Rosato, Antonio;Vitali, Cesare;Milillo, Maria Antonietta
本研究的目的是验证香叶天竺葵（Pelargonium graveolens）[Lis-Balchin，M.，Deans，S. G.，哈特，S.，1996.来自不同商业来源的生物活性香叶油。J. Essential Oil Res. 8，281-290.]精油（及其主要成分）和诺氟沙星抗生素作为第一步，在五种微生物物种中评估某些类型的精油的生长抑制。采用琼脂稀释法（ADM），测定了香荆芥油及其组分对蜡状芽孢杆菌ATCC 11778、枯草芽孢杆菌ATCC 6633、大肠杆菌ATCC 35218、金黄色葡萄球菌ATCC 6538和沙门氏菌的抗菌效果。所获得的结果突出了在所研究的五种细菌物种中的三种的情况下，在P. graveolens精油和诺氟沙星之间发生了显著的协同作用，其中FIC指数在0.37-0.50的范围内。当诺氟沙星与P. graveolens精油的主要成分一起给药时，这种抗菌作用也显示出增加，尽管程度较低。诺氟沙星与R graveolens精油或与后者的一些主要成分的组合，在治疗由某些细菌引起的感染时，很可能使用最低有效剂量的诺氟沙星，从而最大限度地减少抗生素的副作用。(C)2006年Elsevier GmbH。All rights reserved.
The objective of the present study was that of verifying a possible synergistic antibacterial effect between Pelargonium graveolens [Lis-Balchin, M., Deans, S.G., Hart, S., 1996. Bioactive Geranium oils from different commercial sources. J. Essential Oil Res. 8, 281-290.] essential oil (and its main components) and Norfloxacin antibiotic.As a first step growth inhibition by some types of essential oils was assessed in five microbial species. The antimicrobial effects of P. graveolens oil, as well as those of its components, were evaluated by means of the agar dilution method (ADM) against Bacillus cereus ATCC 11778, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 35218, Staphylococcus aureus ATCC 6538 and S. aureus ATCC 29213.The results obtained highlighted the occurrence of a pronounced synergism between P. graveolens essential oil and Norfloxacin against three of the five bacterial species under study with a FIC index in the 0.37-0.50 range. Such antibacterial effects were also shown to increase, although to a lesser extent, when Norfloxacin was given with the main components of P. graveolens essential oil.Significance and impact of the study: The combination of Norfloxacin with either R graveolens essential oil, or with some of the main components of this latter, in the treatment of infections caused by some bacterial species is likely to red Lice the minimum effective dose of Norfloxacin thus minimizing the side effects of the antibiotic. (C) 2006 Elsevier GmbH. All rights reserved.