Urinary cadmium as indicator of renal cadmium in humans: an autopsy study
Urinary cadmium as indicator of renal cadmium in humans: an autopsy study
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DOI：
10.1191/096032798678908792
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发表时间：
1998-06-01
影响因子：
2.8
通讯作者：
Gross, A
中科院分区：
文献类型：
--
作者：
Orlowski, C;Piotrowski, JK;Gross, A
目的：通过对非职业性镉接触者的尸检分析，估算肾皮质和尿镉的当量水平。方法：对39例年龄42+/-14岁的镉接触者的肾皮质、肝脏、尿液和膀胱中镉的含量进行测定。采用火焰原子吸收光谱法(肾脏、肝脏)和无火焰原子吸收光谱分析(尿镉、膀胱镉)。结果：死后尿镉含量与肾脏镉含量有很强的相关性。剔除高尿蛋白血症病例，根据尿蛋白浓度升高的数据外推至正常范围，其值为1.7微克/克肌酐，相当于肾脏的50微克/克体重。结论：尿镉和肾皮质镉的监测数据似乎是一致的。
Objective: To estimate the equivalent cadmium levels in renal cortex and in urine, as based on autopsy analysis of subjects not exposed to cadmium occupationally.Methods: The levels of Cd were determined in renal cortex, liver, urine and urinary bladder of 39 subjects deceased at the age 42 +/- 14 years. Flame atomic absorption spectrometry (kidneys, liver) and flameless AAS (urine, bladder) were used.Results: The urinary cadmium level determined post mortem is strongly correlated with the renal Cd levels. Eliminating cases with high urinary proteins and extrapolating from sets of data with elevated urinary protein concentration to its normal range yielded a value of 1.7 mu g/g creatinine as equivalent to the renal level of 50 mu g/g w.w.Conclusions: It seems possible to use monitoring data for cadmium in urine and in renal cortex in a coherent way.