Differences in finger length ratio between males with autism, pervasive developmental disorder-not otherwise specified, ADHD, and anxiety disorders
Differences in finger length ratio between males with autism, pervasive developmental disorder-not otherwise specified, ADHD, and anxiety disorders
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DOI：
10.1017/s0012162206002118
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发表时间：
2006-12-01
影响因子：
3.8
通讯作者：
Ferdinand, Robert F.
中科院分区：
文献类型：
--
作者：
de Bruin, Esther I.;Verheij, Fop;Ferdinand, Robert F.
自闭症儿童的食指（2D）比无名指（4D）相对较短。通常认为2D：4D比例与胎儿睾酮水平有关，高胎儿睾酮水平可能在自闭症的病因学中发挥作用。目前还不清楚这种效应是否是自闭症特有的。在这项研究中，将144名6至14岁（平均年龄9岁1个月[SD 1岁11个月]）患有精神疾病的男性的2D：4D比值与96名6至13岁的普通人群男性（平均年龄9岁1个月[SD 1岁10个月]）的2D：4D比值进行了比较。精神障碍分为自闭症/巴氏综合征（n=24），广泛性发育障碍-未另行说明（PDD-NOS; n=26），注意缺陷多动障碍（ADHD）/对立违抗性障碍（ODD; n=68），和焦虑症（n=26）。患有自闭症/巴氏综合征（p < 0.05）和ADHD/ODD（p < 0.05）的男性比患有焦虑症的男性的比率显著更低（尽管不显著; p=0.52），患有自闭症/巴氏综合征的男性比对照组的比率更低。这些结果表明，较高的胎儿睾酮水平可能发挥作用，不仅在自闭症的起源，而且在PDD-NOS和ADHD/ODD的病因。患有焦虑症的男性可能在出生前就暴露在较低的睾丸激素水平下。
Children with autism have a relatively shorter index finger (2D) compared with their ring finger (4D). It is often presumed that the 2D:4D ratio is associated with fetal testosterone levels and that high fetal testosterone levels could play a role in the aetiology of autism. It is unknown whether this effect is specific to autism. In this study, 2D:4D ratios of 144 males aged 6 to 14 years (mean age 9y 1mo [SD 1y 11mo]) with psychiatric disorders were compared with those of 96 males aged 6 to 13 years from the general population (mean age 9y 1mo [SD 1y 10mo]). Psychiatric disorders were divided into autism/Asperger syndrome (n=24), pervasive developmental disorder-not otherwise specified (PDD-NOS; n=26), attention-deficit-hyperactivity disorder (ADHD)/oppositional defiant disorder (ODD; n=68), and anxiety disorders (n=26). Males with autism/Asperger syndrome (p < 0.05) and ADHD/ODD (p < 0.05) had significantly lower (though not significantly; p=0.52) ratios than males with an anxiety disorder, and males with autism/Asperger syndrome had lower ratios than those in the comparison group. These results indicated that higher fetal testosterone levels may play a role, not only in the origin of autism, but also in the aetiology of PDD-NOS and of ADHD/ODD. Males with anxiety disorders might have been exposed to lower prenatal testosterone levels.