Cannabis use and blood pressure levels: United States National Health and Nutrition Examination Survey, 2005-2012.
Cannabis use and blood pressure levels: United States National Health and Nutrition Examination Survey, 2005-2012.
复制标题
DOI：
10.1097/hjh.0000000000000990
复制
发表时间：
2016-08
影响因子：
4.9
通讯作者：
Elbaz HA
中科院分区：
文献类型：
--
作者：
Alshaarawy O;Elbaz HA
临床前研究已经报道了大麻的急性心血管效应，包括剂量依赖性的血压升高，而直立性低血压可能是由于血管阻力降低所致。在病例报告中，有证据表明大麻与年轻人和中年人的急性心血管事件有关。在这里，我们提供了2005年至2012年美国国家健康和营养检查调查(n=12426)中关于大麻使用-血压水平的流行病学估计。计算机辅助自我访谈评估了大麻的使用情况。血压是通过在一次检查中平均测量多达四次来确定的。回归模型被用来检验大麻使用与血压的关系。在年龄-性别调整的模型中，最近活跃的大麻使用与收缩压升高相关(β=1.6；95%CI：0.6，2.7)。额外的协变量调整不会影响正相关性。没有发现大麻使用和舒张压之间的联系。在一个相对较大的具有全国代表性的美国成年人样本中，检测到最近吸食大麻与收缩压之间存在适度的关联。随着大麻合法化，有必要对大麻使用对心血管的影响进行临床前、临床和预期人群研究。
Pre-clinical studies have reported acute cardiovascular effects of cannabis including a dose-dependent increase in blood pressure while orthostatic hypotension may follow as a result of decreased vascular resistance. In case reports, evidence links cannabis with acute cardiovascular events in young and middle aged adults. Here, we offer epidemiologic estimates on cannabis use-blood pressure levels association from the United States (US) National Health and Nutrition Examination Surveys 2005–2012 (n=12426). Computer-assisted self-interviews assessed cannabis use. Blood pressure was determined by an average of up to four measurements taken during a single examination. Regression modeling was used to examine cannabis use– blood pressure association. Recently active cannabis use was associated with increase in systolic blood pressure (β = 1.6; 95% CI: 0.6, 2.7) in the age-sex adjusted model. Additional covariate adjustment did not affect the positive association. No association between cannabis use and diastolic blood pressure was detected. A modest association between recent cannabis use and systolic blood pressure was detected among a relatively large nationally representative sample of US adults. With the legalization of cannabis, there a need for pre-clinical, clinical and prospective population-based research on the cardiovascular effects of cannabis use.