Human Medial Orbitofrontal Cortex Is Recruited During Experience of Imagined and Real Rewards
Human Medial Orbitofrontal Cortex Is Recruited During Experience of Imagined and Real Rewards
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DOI：
10.1152/jn.01030.2009
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发表时间：
2010-05-01
影响因子：
2.5
通讯作者：
O'Doherty, John P.
中科院分区：
文献类型：
--
作者：
Bray, Signe;Shimojo, Shinsuke;O'Doherty, John P.
Bray S，Shimojo S，O‘Doherty JP.人类内侧眶前叶皮质是在体验想象和真实奖励的过程中被招募的。神经生理学杂志103：2506-2512,2010。2010年3月3日首次出版；DOI：10.1152/jn.01030.2009。人类的决策经常依赖于对未来回报的心理模拟来指导行动选择。在这项研究中，我们试图发现在奖励图像中参与的大脑区域，并解决这些区域是否在功能上与有形奖励激活的区域重叠。我们发现，内侧眼眶前额叶皮质(MOFC)参与了真实奖赏和想象奖赏，与其他非奖赏表象相比，它优先参与具有奖赏内容的表象。这些发现支持了mOFC在表现奖励目标状态方面的关键作用，即使是假设的。
Bray S, Shimojo S, O'Doherty JP. Human medial orbitofrontal cortex is recruited during experience of imagined and real rewards. J Neurophysiol 103: 2506-2512, 2010. First published March 3, 2010; doi: 10.1152/jn.01030.2009. Human decision-making frequently relies on mental simulation of future rewards to guide action choice. In this study, we sought to uncover brain regions engaged during reward imagery and to address whether these regions functionally overlap with regions activated by tangible rewards. We found that medial orbitofrontal cortex (mOFC) is engaged both for real and imagined rewards and is preferentially engaged for imagery with rewarding content compared with other nonrewarding imagery. These findings support a critical role for mOFC in the representation of rewarding goal states, even if hypothetical.