A novel mechanism of angiotensin II-regulated placental vascular tone in the development of hypertension in preeclampsia.
A novel mechanism of angiotensin II-regulated placental vascular tone in the development of hypertension in preeclampsia.
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血管紧张素II调节胎盘血管张力在子痫前期高血压发展中的新机制
DOI：
10.18632/oncotarget.15416
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发表时间：
2017-05-09
期刊：
影响因子：
--
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Gao Q;Tang J;Li N;Zhou X;Li Y;Liu Y;Wu J;Yang Y;Shi R;He A;Li X;Zhang Y;Chen J;Zhang L;Sun M;Xu Z
本研究验证了血管紧张素II在调节胎盘血管张力中发挥作用的假设，这有助于先兆子痫的高血压。在人和动物的大型和微型胎盘和非胎盘血管中进行功能和分子测定。在人胎盘血管中，血管紧张素II在155次试验中诱导了78.7%血管的血管收缩，与KCl诱导的收缩相比。相比之下，在133次测试中，苯乙哌啶仅产生了3.0%的收缩。在非胎盘血管中，苯肾上腺素在67次试验中的76.0%引起收缩，而血管紧张素II在75次试验中未能引起收缩。在动物胎盘和非胎盘血管中获得了相似的结果。与非胎盘血管相比，胎盘血管中血管紧张素II受体和β肾上腺素受体明显增加。与正常妊娠的血管相比，血管紧张素II诱导的血管收缩在先兆子痫胎盘中显著减少，这与血管紧张素II受体的减少有关。此外，血管紧张素II和血管紧张素转换酶在母体-胎盘循环在先兆子痫增加，而血管紧张素I和血管紧张素1 -7浓度不变。这项研究表明，血管紧张素II在维持胎盘血管张力的选择性作用，这可能在子痫前期高血压的发展中发挥重要作用。
The present study tested the hypothesis that angiotensin II plays a role in the regulation of placental vascular tone, which contributes to hypertension in preeclampsia. Functional and molecular assays were performed in large and micro placental and non-placental vessels from humans and animals. In human placental vessels, angiotensin II induced vasoconstrictions in 78.7% vessels in 155 tests, as referenced to KCl-induced contractions. In contrast, phenylephrine only produced contractions in 3.0% of 133 tests. In non-placental vessels, phenylephrine induced contractions in 76.0% of 67 tests, whereas angiotensin II failed to produce contractions in 75 tests. Similar results were obtained in animal placental and non-placental vessels. Compared with non-placental vessels, angiotensin II receptors and β -adrenoceptors were significantly increased in placental vessels. Compared to the vessels from normal pregnancy, angiotensin II-induced vasoconstrictions were significantly reduced in preeclamptic placentas, which was associated with a decrease in angiotensin II receptors. In addition, angiotensin II and angiotensin converting enzyme in the maternal-placenta circulation in preeclampsia were increased, whereas angiotensin I and angiotensin1-7 concentrations were unchanged. The study demonstrates a selective effect of angiotensin II in maintaining placental vessel tension, which may play an important role in development of hypertension in preeclampsia.