NITRIC-OXIDE EVOKES PAIN IN HUMANS ON INTRACUTANEOUS INJECTION
NITRIC-OXIDE EVOKES PAIN IN HUMANS ON INTRACUTANEOUS INJECTION
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DOI：
10.1016/0304-3940(94)90712-9
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发表时间：
1994-01-03
影响因子：
2.5
通讯作者：
ARNDT, JO
中科院分区：
文献类型：
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作者：
HOLTHUSEN, H;ARNDT, JO
为了验证一氧化氮（NO）在人体中起代数作用的假设，我们确定了静脉注射NO溶液的疼痛强度/剂量关系。将溶解于等摩尔磷酸盐缓冲液中的一氧化氮注射于6名志愿者的前臂，并在电子控制视觉模拟量表的帮助下对一氧化氮引起的疼痛进行持续评分。疼痛总是在NO剂量为12 nmol时发生，随剂量增加而增加，在50 nmol时达到耐受性最大值。这第一次显示了NO的真正的疼痛唤起特性。
To test the hypothesis that nitric oxide (NO) acts algetically in humans, we determined pain intensity/dose relations for intracutaneously applied NO solutions. NO, dissolved in isoosmolar phosphate buffer, was injected in the forearm of six volunteers and the subjects rated NO-evoked pain continuously with the help of an electronically controlled visual analogue scale. Pain always occurred at a NO dose of 12 nmol, increased with dose and reached the tolerance maximum at 50 nmol. This shows for the first time the genuine pain evoking properties of NO.