Examining the profile of high-potency cannabis and its association with severity of cannabis dependence.
Examining the profile of high-potency cannabis and its association with severity of cannabis dependence.
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DOI：
10.1017/s0033291715001178
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发表时间：
2015-11
影响因子：
6.9
通讯作者：
Winstock AR
中科院分区：
文献类型：
--
作者：
Freeman TP;Winstock AR
在英格兰和威尔士，大麻的使用正在减少，而成瘾服务中对大麻治疗的需求继续上升。这可能部分是由于高效力大麻的供应增加。居住在英国的成年人被问及他们的药物使用情况，包括三种类型的大麻（高效力：臭鼬;低效力：其他草，树脂）。对大麻类型进行了分析，并研究了使用频率与（一）大麻依赖性，（二）大麻相关问题之间的可能联系。频繁使用高效大麻预示着更严重的依赖性[每月使用臭鼬的天数：B = 0.254，95%置信区间（CI）0.161-0.357，p < 0.001]，并且随着年龄的降低，这种影响变得更强（B =-0.006，95% CI-0.010至-0.002，p = 0.004）。相比之下，使用低效力大麻与依赖性无关（每月使用其他草的天数：B = 0.020，95% CI-0.029至0.070，p = 0.436;每月使用树脂的天数：B = 0.025，95% CI-0.019至0.067，p = 0.245）。使用大麻的频率（所有类型）并不能预测大麻相关问题的严重程度。高效能大麻与低效能大麻品种的明显区别在于其对记忆和偏执的显著影响。它也产生了最好的高，是首选，最可用的。高效力大麻的使用与依赖性的严重程度增加有关，特别是在年轻人中。其特征主要由负面影响（记忆、偏执）和积极特征（最佳高、首选类型）决定，在考虑侧重于大麻效力的临床或公共卫生干预措施时，这一点可能很重要。
Cannabis use is decreasing in England and Wales, while demand for cannabis treatment in addiction services continues to rise. This could be partly due to an increased availability of high-potency cannabis. Adults residing in the UK were questioned about their drug use, including three types of cannabis (high potency: skunk; low potency: other grass, resin). Cannabis types were profiled and examined for possible associations between frequency of use and (i) cannabis dependence, (ii) cannabis-related concerns. Frequent use of high-potency cannabis predicted a greater severity of dependence [days of skunk use per month: b = 0.254, 95% confidence interval (CI) 0.161–0.357, p < 0.001] and this effect became stronger as age decreased (b = −0.006, 95% CI −0.010 to −0.002, p = 0.004). By contrast, use of low-potency cannabis was not associated with dependence (days of other grass use per month: b = 0.020, 95% CI −0.029 to 0.070, p = 0.436; days of resin use per month: b = 0.025, 95% CI −0.019 to 0.067, p = 0.245). Frequency of cannabis use (all types) did not predict severity of cannabis-related concerns. High-potency cannabis was clearly distinct from low-potency varieties by its marked effects on memory and paranoia. It also produced the best high, was preferred, and most available. High-potency cannabis use is associated with an increased severity of dependence, especially in young people. Its profile is strongly defined by negative effects (memory, paranoia), but also positive characteristics (best high, preferred type), which may be important when considering clinical or public health interventions focusing on cannabis potency.