Alpha-fetoprotein in serum and tumor tissues in dogs with hepatocellular carcinoma
Alpha-fetoprotein in serum and tumor tissues in dogs with hepatocellular carcinoma
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DOI：
10.1177/104063870601800312
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发表时间：
2006-05-01
影响因子：
1.5
通讯作者：
Kobayashi, K
中科院分区：
文献类型：
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作者：
Kitao, S;Yamada, T;Kobayashi, K
对四只患有肝细胞癌 (HCC) 的狗进行手术切除肿瘤块之前和之后测量血清甲胎蛋白 (AFP) 浓度。还通过免疫组织化学方法检查了肿瘤组织中 AFP 的定位。其中3例，血清AFP浓度比正常犬高10至20倍。术后1～2个月，血清AFP浓度已降至正常范围。在这三个病例中，AFP 定位于肿瘤组织中。 1 例血清 AFP 较低，但未显示 AFP 在肿瘤组织中的定位。
Serumalpha-fetoprotein (AFP) concentrations were measured before and after surgical removal of tumor masses in four dogs with hepatocellular carcinoma (HCC). Localization of AFP was also examined immunohistochemically in tumor tissues. In three cases, the serum AFP concentration was 10 to 20 times higher than that of normal dogs. One to two months after surgery, the serum AFP concentration had decreased to normal range. AFP was localized in the tumor tissues in these three cases. One case, which had a low serum AFP, did not show AFP localization in tumor tissue.