Identification of a promoter motif regulating the major DNA damage response mechanism of Mycobacterium tuberculosis
Identification of a promoter motif regulating the major DNA damage response mechanism of Mycobacterium tuberculosis
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DOI：
10.1016/j.femsle.2004.07.017
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发表时间：
2004-09-01
影响因子：
2.1
通讯作者：
Ahel, I
中科院分区：
文献类型：
--
作者：
Gamulin, V;Cetkovic, H;Ahel, I
许多细菌对DNA损伤的主要反应是由依赖于莱克萨和RecA蛋白的机制介导的。然而，结核分枝杆菌最近报道，调节大多数的DNA修复基因的独立RecA和莱克萨，这表明一个未知的RecA/LexA独立的机制控制的主要DNA损伤反应途径，在这种生物体。在这里，我们已经确定了一个基序tTGTCRgtg-8 nt-TAnnnT，定义了一个新的RecA/LexA非依赖性启动子（RecA-NDp）。结核此外，我们表明，RecA-NDp型的启动子先于DNA修复基因在其他放线菌目。(C)2004年，欧洲微生物学会联合会。Elsevier B. V.出版，保留所有权利。
The principal response of many bacteria to DNA damage is mediated by a mechanism dependent on the LexA and RecA proteins. However, Mycobacterium tuberculosis was recently reported to regulate a majority of DNA repair genes independently of RecA and LexA, suggesting that an unknown RecA/LexA-independent mechanism controls the major DNA damage response pathway in this organism. Here we have identified a motif tTGTCRgtg-8nt-TAnnnT that defines a novel RecA/LexA-independent promoter (RecA-NDp) of M. tuberculosis. Furthermore, we show that the RecA-NDp type of promoter precedes DNA repair genes in other Actinomycetales. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.