Social anxiety predicts amygdala activation in adolescents viewing fearful faces
Social anxiety predicts amygdala activation in adolescents viewing fearful faces
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DOI：
10.1097/01.wnr.0000180143.99267.bd
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发表时间：
2005-10-17
期刊：
影响因子：
1.7
通讯作者：
Yurgelun-Todd, DA
中科院分区：
文献类型：
--
作者：
Killgore, WDS;Yurgelun-Todd, DA
杏仁核在成人焦虑的处理过程中起着至关重要的作用，但对青春期特质焦虑的神经发生却知之甚少。我们将恐惧和快乐面孔的视觉呈现与16名接受功能磁共振成像的青少年儿童多维焦虑量表得分相关联。在恐惧感知过程中，杏仁核活动与焦虑的几个社会维度呈正相关，包括同伴排斥、羞辱、在公共场合表演和与亲人分离，但与大多数测量的非社会维度的焦虑无关。快乐面孔呈现时的杏仁核反应仅与紧张/不安呈正相关。在青春期，杏仁核活动似乎与社会/人际焦虑的关系比非社会焦虑的关系更强。
The amygdala is critically involved in the processing of anxiety in adults, but little is known about the neurogenesis of trait-anxiety during adolescence. We correlated amygdala activity during visual presentations of fearful and happy faces with scores on the Multidimensional Anxiety Scale for Children in 16 adolescents undergoing functional magnetic resonance imaging. During fear perception, amygdala activity positively correlated with several social dimensions of anxiety, including peer rejection, humiliation, performing in public, and being separated from loved ones, but was not correlated with most measured nonsocial dimensions of anxiety. Annygdala responses during happy face presentations correlated positively only with tension/restlessness. During adolescence, amygdala activity appears to be more strongly related to social/interpersonal than nonsocial dimensions of anxiety.