Antimicrobial susceptibility patterns of thermophilic Campylobacter spp. from humans, pigs, cattle, and broilers in Denmark
Antimicrobial susceptibility patterns of thermophilic Campylobacter spp. from humans, pigs, cattle, and broilers in Denmark
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DOI：
10.1128/aac.41.10.2244
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发表时间：
1997-10-01
影响因子：
4.9
通讯作者：
Engberg, J
中科院分区：
文献类型：
--
作者：
Aarestrup, FM;Nielsen, EM;Engberg, J
在丹麦测定了16种抗菌药物对202株空肠弯曲菌分离株、123株结肠弯曲菌分离株和6株拉里弯曲菌分离株的MIC。空肠弯曲杆菌分离株来自人（75）、肉鸡（95）、牛（29）和猪（3）;来自人（7）、肉鸡（17）和猪（99）的大肠杆菌分离株;所有分离株均对安普霉素、新霉素和庆大霉素敏感，只有少数空肠弯曲菌对一种或多种抗菌药物耐药，人源空肠弯曲菌对四环素的耐药率（11%）高于动物源空肠弯曲菌（0 ~ 2%），空肠弯曲菌牛源分离株（10%）高于人源（4%）和肉鸡源（1%）;空肠弯曲菌对其他抗菌药物的耐药率高于大肠杆菌。大多数分离株对泰乐菌素、螺旋霉素和红霉素同时耐药或对三种抗生素均敏感。猪源大肠杆菌感染率（79%）高于猪源大肠杆菌。猪源大肠杆菌对恩诺沙星耐药率为24%，人源大肠杆菌耐药率为29%，肉鸡源大肠杆菌无耐药。6株大肠埃希菌对除氨苄西林和萘啶酸外的所有抗菌药物均敏感。jejuni和C.从猪源分离的弯曲菌对大环内酯类和链霉素耐药率较高，不同来源的弯曲菌对抗菌药物的耐药性存在差异。
The MICs of 16 antimicrobial agents were determined for 202 Campylobacter jejuni isolates, 123 Campylobacter coli isolates, and 6 Campylobacter lari isolates from humans and food animals in Denmark. The C.jejuni isolates originated from humans (75), broilers (95), cattle (29), and pigs (3); the C. coil isolates originated from humans (7), broilers (17), and pigs (99); and the C. lari isolates originated from broilers (5) and cattle (1), All isolates were susceptible to apramycin, neomycin, and gentamicin, Only a few C.jejuni isolates were resistant to one or more antimicrobial agents, Resistance to tetracycline was more common among C.jejuni isolates from humans (11%) than among C, jejuni isolates from animals (0 to 2%), More resistance to streptomycin was found among C, jejuni isolates from cattle (10%) than among those from humans (4%) or broilers (1%), A greater proportion of C. coil than of C, jejuni isolates were resistant to the other antimicrobial agents tested. Isolates were in most cases either coresistant to tylosin, spiramycin, and erythromycin or susceptible to all three antibiotics, More macrolide-resistant isolates were observed among C. coil isolates from swine (79%) than among C. coil isolates from broilers (18%) and humans (14%), Twenty-four percent of C, coli isolates from pigs were resistant to enrofloxacin, whereas 29% of C, coli isolates from humans and none from broilers were resistant, More resistance to streptomycin was observed among C, coil isolates from swine (48%) than among C. coil isolates from broilers (6%) or humans (0%), The six C, lari isolates were susceptible to all antimicrobial agents except ampicillin and nalidixic acid, This study showed that antimicrobial resistance was found only at relatively low frequencies among C. jejuni and C, lari isolates, Among C. coil isolates, especially from swine, there was a high level of resistance to macrolides and streptomycin, Furthermore, this study showed differences in the resistance to antimicrobial agents among Campylobacter isolates of different origins.