Migration and risk of schizophrenia and bipolar disorder: A Swedish national study.
Migration and risk of schizophrenia and bipolar disorder: A Swedish national study.
复制标题
移民与精神分裂症和双相情感障碍的风险：瑞典国家研究。
DOI：
10.1016/j.schres.2023.08.022
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发表时间：
2023
影响因子：
4.5
通讯作者：
Bergen,SarahE
中科院分区：
文献类型：
--
作者：
Robinson,Natassia;Ploner,Alexander;Müller-Eberstein,Roxana;Lichtenstein,Paul;Kendler,KennethS;Bergen,SarahE
以前的研究报告精神分裂症（SCZ）的风险增加，移民相对于本地出生的人口;然而，很少有研究双相情感障碍（BD）和移民的特点，可能会影响风险。我们的目的是检查SCZ和BD在移民及其子女相对于瑞典血统的风险，以及风险是否因移民年龄，原籍地区，性别和父母移民身份而异。按出生年份和性别分别与5个基于人群的对照组相匹配。条件Logistic回归被用来评估SCZ和BD的风险移民身份，原籍地区和年龄在迁移，与模型分层sexual. ResultsFirst代移民增加了SCZ的风险和BD的风险降低。有一个独特的模式的风险SCZ的年龄在迁移。来自所有地区的儿童移民增加了SCZ的风险，特别是来自非洲的儿童移民。相反，BD的风险随着移民年龄的增长而下降，仅在北欧儿童移民中风险增加。SCZ和BD诊断下降，在成年移民，升高的第二代移民（风险不同的移民父母和更大的那些与移民父亲）和更高的男性移民（与女性）。需要进一步的研究来确定与移民有关的因素如何影响疾病的病因和这些诊断的接受。
ObjectivePrior studies report increased risk of schizophrenia (SCZ) in migrants relative to the native-born population; however, few have investigated bipolar disorder (BD) and migrant characteristics which may influence risk. We aimed to examine the risk of SCZ and BD in migrants and their children relative to those of Swedish ancestry, and whether risk varied by age at migration, region of origin, sex, and parental migrant status.MethodsWe conducted a nested case-control study using 5539 SCZ cases and 20,577 BD cases diagnosed 1988–2013, individually matched to five population-based controls by birth year and sex. Conditional logistic regression was used to evaluate the risk of SCZ and BD by migrant status, region of origin and age at migration, with models stratified by sex.ResultsFirst-generation migrants had increased risk of SCZ and decreased risk of BD. There was a distinct pattern of risk for SCZ by age at migration. Childhood migrants from all regions had increased risk of SCZ, particularly those from Africa. In contrast, risk for BD declined with age at migration, with increased risk only in Nordic child migrants. SCZ and BD diagnoses were decreased in adult migrants, elevated in second-generation migrants (with risk differing by number of migrant parents and greater for those with migrant fathers) and higher in male migrants (vs. female).ConclusionsAge at migration, sex, and region of origin affect risk of SCZ and BD. Further research is required to determine how migration-related factors influence disease etiology and the receipt of these diagnoses.