THE EFFECTS OF CYCLOSPORINE-A ON LYMPHOCYTE-T AND DENDRITIC CELL SUBPOPULATIONS IN PSORIASIS
THE EFFECTS OF CYCLOSPORINE-A ON LYMPHOCYTE-T AND DENDRITIC CELL SUBPOPULATIONS IN PSORIASIS
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DOI：
10.1111/j.1365-2133.1987.tb05869.x
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发表时间：
1987-04-01
影响因子：
10.3
通讯作者：
FRY, L
中科院分区：
文献类型：
--
作者：
BAKER, BS;GRIFFITHS, CEM;FRY, L
连续皮肤活检6例严重银屑病患者进行了研究，在治疗期间与环孢素。其中4名患者完全清楚，其余2名患者明显改善。在病变表皮中观察到树突状细胞的亚群，HLA-DR+，但缺乏朗格汉斯细胞（DR + 6-）特征性表达的T6抗原。它们在治疗期间消失，在临床改善明显之前，并且以与银屑病清除相关的速率消失。这些细胞在正常或未受累的银屑病表皮中未发现，它们在皮损皮肤中的数量似乎与疾病的临床严重程度有关。在临床改善之前，表皮和真皮中的CD 4和CD 8以及HLA-DR+ CD 8 T细胞的总数显著降低。相反，在消退过程中，表皮中HLA-DR+ CD 4 T细胞的数量通常没有减少，而这些细胞在真皮中平均减少68%。环孢菌素在银屑病中的有益作用进一步支持了T细胞在银屑病发病机制中发挥核心作用的假设。在环孢素治疗期间在皮肤中观察到的细胞变化可能有助于阐明该药物对人体免疫调节机制的影响。
Sequential skin biopsies from six patients with severe psoriasis were studied during treatment with cyclosporin. Four of the patients clearly completely and the remaining two showed a marked improvement. A subset of dendritic cells, HLA-DR+ but lacking the T6 antigen characteristically expressed by Langerhans cells (DR + 6-), was observed in lesional epidermis. They disappeared during treatment, before clinical improvement was apparent and at a rate which correlated with clearance of psoriasis. These cells were not found in normal or uninvolved psoriatic epidermis and their number in lesional skin appeared to be related to the clinical severity of the disease. Total numbers of CD4 and CD8, and HLA-DR+ CD8T cells were substantially reduced in both epidermis and dermis prior to clinical improvement. In contrast, there was generally no decrease in the number of HLA-DR+ CD4 T cells in the epidermis during resolution, whereas these cells were reduced by an average of 68% in the dermis. The beneficial effects of cyclosporin in psoriasis further support the hypothesis that T cells play a central role in the pathogenesis of psoriasis. The cellular changes observed in the skin during cyclosporin treatment may help to elucidate the effects of this drug on immunoregulatory mechanisms in man.