Trp-Trp acts as a multi-functional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46.
Trp-Trp acts as a multi-functional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46.
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Trp-Trp 是人类苦味受体 hTAS2R14、hTAS2R16、hTAS2R43 和 hTAS2R46 的多功能阻滞剂。
DOI：
10.1093/bbb/zbab061
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
K. Ito
中科院分区：
文献类型：
--
作者：
I. Ojiroa;H. Nishioa;T. Yamazaki-Ito;S. Nakanoa;S. Ito;Y. Toyohara;T. Hiramoto;Y. Terada;K. Ito
许多功能性食品成分激活人类苦味受体（hTAS 2 Rs）。本研究通过寻找hTAS 2 R14的激动肽类似物，发现了一种新的hTAS 2 R14抑制剂Trp-Trp。Trp-Trp还抑制hTAS 2 R16、hTAS 2 R43和hTAS 2 R46，它们与hTAS 2 R14共享相同的激动剂。Trp-Trp的多功能特性有利于在功能性食品中用作苦味掩蔽剂。
Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multifunctional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.