Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH)—Phase Ib: Effect of morphology on hemodynamics
Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH)—Phase Ib: Effect of morphology on hemodynamics
复制标题
2018 年多发性动脉瘤解剖挑战 (MATCH) — 第 Ib 期：形态对血流动力学的影响
作者：
S. Voß;O. Beuing;G. Janiga;P. Berg
背景基于图像的血流模拟已越来越多地应用于研究颅内动脉瘤(IA)的血流动力学。然而，由于基本假设和结果质量的高度可变性，医生的接受度仍然有限。方法为了评估血管分割作为最重要的误差来源之一，公布了2018年国际多发性动脉瘤解剖挑战赛(Match)。来自13个不同国家的26个研究小组分割了三个数据集，总共包含五个国际会计准则。在这些分割的基础上，在一致条件下进行了73个随时间变化的血流模拟。然后，对相关的流动和剪切参数(如颈部流量、母体血管流量、空间平均速度和壁面剪应力)进行了定性和定量的分析。结果对于整个血管系统，分段血管半径的变异性为0.13 mm，与局部血管半径无关。然而，在更远端的血管中，中心线速度显示出更多的变异性。聚焦于动脉瘤，在形态和血流动力学参数上观察到明显的差异。对节段引起的变异性的量化显示，不同组间的载瘤血管流速约有14%的差异。对于平均动脉瘤速度和颈血流速度，分别观察到30%和46%的变化。最后，时间平均壁切应力在28%到51%之间变化，这取决于所讨论的动脉瘤。结论Match揭示了最先进的分割算法对后续IA研究的血流动力学模拟的影响。观察到的变化可能会导致对模拟结果的不适当解释，从而可能导致医生得出不适当的结论。因此，为了获得可靠的临床有用的血流信息，需要对感兴趣区域进行准确的分割。
Background Image-based blood flow simulations have been increasingly applied to investigate intracranial aneurysm (IA) hemodynamics. However, the acceptance among physicians remains limited due to the high variability in the underlying assumptions and quality of results. Methods To evaluate the vessel segmentation as one of the most important sources of error, the international Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH) was announced. 26 research groups from 13 different countries segmented three datasets, which contained five IAs in total. Based on these segmentations, 73 time-dependent blood flow simulations under consistent conditions were carried out. Afterwards, relevant flow and shear parameters (e.g., neck inflow rate, parent vessel flow rate, spatial mean velocity, and wall shear stress) were analyzed both qualitatively and quantitatively. Results Regarding the entire vasculature, the variability of the segmented vessel radius is 0.13 mm, consistent and independent of the local vessel radius. However, the centerline velocity shows increased variability in more distal vessels. Focusing on the aneurysms, clear differences in morphological and hemodynamic parameters were observed. The quantification of the segmentation-induced variability showed approximately a 14% difference among the groups for the parent vessel flow rate. Regarding the mean aneurysmal velocity and the neck inflow rate, a variation of 30% and 46% was observed, respectively. Finally, time-averaged wall shear stresses varied between 28% and 51%, depending on the aneurysm in question. Conclusions MATCH reveals the effect of state-of-the-art segmentation algorithms on subsequent hemodynamic simulations for IA research. The observed variations may lead to an inappropriate interpretation of the simulation results and thus, can lead to inappropriate conclusions by physicians. Therefore, accurate segmentation of the region of interest is necessary to obtain reliable and clinically helpful flow information.
影响因子：
2.4
作者：
Bakhshinejad A;Baghaie A;Vali A;Saloner D;Rayz VL;D'Souza RM
通讯作者：
D'Souza RM