Severe Intravascular Haemolysis in a Renal Transplant Recipient due to Anti‐B of Donor Origin
Severe Intravascular Haemolysis in a Renal Transplant Recipient due to Anti‐B of Donor Origin
复制标题
肾移植受者因供体来源的抗 B 抗体导致严重血管内溶血
作者：
J. Orchard;N. Young;C. Smith;S. Thomas;C. Darke
抽象的。由于抗B抗体的形成，0组肾脏的B组受体发生重度血管内溶血。供体血清、受体血清和“非预期”抗B抗体的免疫球蛋白同种异型分型显示抗体为供体来源。患者和供体基因型分别为Gm 3;5/3;5和Gm 1，2;21/1;21，抗B抗体同种异型为Gm 1;21。另一个供体肾的B组受体未显示溶血迹象。影响移植后溶血发生和严重程度的可能因素进行了讨论。接受0组器官移植的非0组患者中抗A或抗B抗体的产生已得到充分描述[1-8]。我们报告一例严重的血管内溶血的B组患者谁收到了0组肾脏，连同免疫球蛋白同种异型研究，最终表明，负责溶血的抗体是供体来源。
Abstract. A group B recipient of a group 0 kidney developed severe intravascular haemolysis due to the formation of anti‐B. Immunoglobulin allotyping of donor serum, recipient serum and ‘unexpected’ anti‐B antibody showed the antibody to be of donor origin. The patient and donor genotypes were Gm 3;5/3;5 and Gm 1,2;21/1;21, respectively, and the anti‐B antibody allotype was Gm 1;21. The group B recipient of the other donor kidney showed no evidence of haemolysis. Possible factors influencing the occurrence and severity of post‐transplantation haemolysis are discussed. The production of anti‐A or anti‐B antibodies in non‐group 0 patients who receive group 0 organ transplants is well described [1–8]. We report a case of severe intravascular haemolysis in a group B patient who received a group 0 kidney, together with immunoglobulin allotyping studies which show conclusively that the antibody responsible for the haemolysis was of donor origin.