EXPERIMENTAL AND CLINICAL PHARMACOLOGY OF METAMPICILLIN IN THE BILIARY TRACT
EXPERIMENTAL AND CLINICAL PHARMACOLOGY OF METAMPICILLIN IN THE BILIARY TRACT
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DOI：
10.1093/jac/2.4.363
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发表时间：
1976-01-01
影响因子：
5.2
通讯作者：
LAVILLAUREIX J
中科院分区：
文献类型：
--
作者：
BROGARD J M;PINGET M;LAVILLAUREIX J
离体兔肝灌注研究表明，氨氨苄青霉素以较高速率经肝脏排泄;胆汁回收率为给药剂量的46.5%。肝摄取氨氨苄青霉素似乎是早期和明显的。在人体中，这种抗生素的胆汁消除根据给药途径而变化。口服氨氨苄青霉素后仅获得中等胆汁浓度，而使用静脉途径时达到极高的胆汁浓度。当胃肠外给药时，氨氨苄青霉素似乎特别适用于胆道感染的治疗。
Investigations with perfusions of isolated rabbit liver showed that metampicillin is excreted by the liver at a high rate; bile recovery is 46.5% of the administered dose. Hepatic uptake of metampicillin seems to be early and pronounced. In man, the biliary elimination of this antibiotic varies according to the route of administration. Only moderate biliary levels were obtained after oral administration of metampicillin, while extremely high biliary concentrations were reached when the i.v. route was used. When administered parenterally, metampicillin appears to be particularly suitable for the treatment of biliary tract infections.