Anti-implantation effect of a carbamate fungicide mancozeb in albino mice
Anti-implantation effect of a carbamate fungicide mancozeb in albino mice
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DOI：
10.2486/indhealth.40.191
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发表时间：
2002-04-01
影响因子：
2
通讯作者：
Kaliwal, BB
中科院分区：
文献类型：
--
作者：
Bindali, BB;Kaliwal, BB
以18、24、30和36 mg/kg体重/d的剂量对正常的未交配的瑞士白化病小鼠给药代森锰锌（一种有机氨基甲酸酯杀真菌剂）8天，以检查对妊娠小鼠着床的影响。于妊娠第9天处死小鼠，记录阴道涂片及体重。在36 mg代森锰锌处理的小鼠中，着床完全受到抑制，着床前丢失率为100%。24和30 mg代森锰锌处理的小鼠的着床受到部分抑制，着床前丢失率分别为53.44%和90.16%。然而，与油处理的对照组相比，在18 mg代森锰锌处理的小鼠中着床不受影响，着床前丢失率为4.92%。为了研究时间效应，口服有效剂量36 mg/kg体重/d代森锰锌3天和5天，仅在第3天给药。在5天处理的小鼠中存在完全的着床抑制，具有100%的着床前丢失，并且在3天处理的小鼠中存在部分的着床抑制，具有75%的着床前丢失。然而，与对照小鼠相比，在第3天处理的小鼠中着床不受影响，仅着床前丢失1.63%。在发情间期有一个显着的减少，结果是在发情期有一个伴随的增加，有一个显着的子宫重量下降，24，30和36毫克代森锰锌治疗3和5天。代森锰锌对着床的抑制可能是由于激素失衡或其毒性作用。
Mancozeb, an organocarbamate fungicide, was administered to examine the effect on implantation at doses of 18, 24, 30 and 36 mg/kg body weight/d to normal virgin swiss albino mice for 8 days to pregnant mice. The vaginal smear and body weight of the mice were recorded day and mice were sacrificed on 9th day of pregnancy. There was a complete inhibition of implantation in 36 mg mancozeb treated mice with 100% pre-implantation loss. There was a partial inhibition of implantation in 24 and 30 mg mancozeb treated mice with 53.44 and 90.16% pre-implantation loss respectively. However, implantation was not affected in 18 mg mancozeb treated mice with 4.92% pre-implantation loss when compared to oil treated controls. To study the temporal effect, the effective dose of 36 mg/kg body weight/d mancozeb was administered orally for 3 and 5 days and on day 3 only. There was a complete inhibition of implantation in 5 days treated mice with 100% pre-implantation loss and partial inhibition of implantation of 3 days treated mice with 75% pre-implantation loss. However, implantation was not affected in mice treated on day 3 only with 1.63% pre-implantation loss when compared to control mice. There was a significant decrease in the diestrus phase with the result there was a concomitant increase in the estrus phase and there was a significant decrease in the uterus weight with 24,30 and 36 mg and for 3 and 5 days with 36 mg mancozeb treatment. Inhibition of implantation by mancozeb may be due to hormonal imbalance or its toxic effects.