The relationship between apolipoprotein (apo) E polymorphism and lipid changes: An 8-year cohort study in Beijing elderly persons
The relationship between apolipoprotein (apo) E polymorphism and lipid changes: An 8-year cohort study in Beijing elderly persons
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DOI：
10.1016/j.archger.2011.12.001
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发表时间：
2012-11-01
影响因子：
4
通讯作者：
Chan, Piu
中科院分区：
文献类型：
--
作者：
Guan, Shaochen;Yang, Jingfang;Chan, Piu
本研究旨在探讨载脂蛋白E基因多态性对中国社区老年人群8年间血脂变化的影响。8年后检测血脂及载脂蛋白E基因分型。ApoE等位基因频率分别为9.4%、81.7%和8.9%。根据载脂蛋白E等位基因携带者的不同分为3组，载脂蛋白E基因2、3和4的载脂蛋白E携带者分别为121例(16.2%)、513例(68.8%)和112例(15.0%)。基线时，epsilon 2携带者的总胆固醇(TC)和低密度脂蛋白(LDL)水平低于epsilon 3等位基因携带者。8年后，随着年龄的增长，TC和高密度脂蛋白(HDL)升高，低密度脂蛋白(LDL)降低(p<；0.01)。与epsilon 3等位基因携带者相比，epsilon 2等位基因携带者的TC水平变化较小。在控制了年龄、性别、吸烟状况、饮酒习惯、体重指数(BMI)和基线TC水平后，差异仍有统计学意义。Epsilon 2和epsilon 3等位基因携带者之间的低密度脂蛋白的变化趋势相同。然而，epsilon 4和epsilon 3等位基因携带者在血脂变化方面没有显著差异。这项基于社区的研究表明，epsilon 2等位基因对血脂变化有帮助。在这一老年人群中，epsilon 4等位基因对血脂变化的影响不强。遗传因素和环境因素可能共同作用于老年人的脂代谢。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
This study aimed to investigate the influence of apoE genetic polymorphism on serum lipid changes in a community-based elderly population in China in an 8-year period, in which 746 individual, aged 65.29 +/- 6.85 years (mean +/- standard deviation (SD)) were enrolled and serum lipid parameters were checked at baseline. After 8 years, serum lipids as well as apoE genotypes were measured. The frequencies of apoE allele were 9.4%, 81.7%, and 8.9% for epsilon 2, epsilon 3 and epsilon 4, respectively. After the population was divided into 3 groups by different apoE allele carriers, the apoE allele carriers for epsilon 2, epsilon 3 and epsilon 4 were 121 (16.2%), 513 (68.8%) and 112 (15.0%), respectively. Levels of total cholesterol (TC) and low density lipoprotein (LDL) in epsilon 2 carriers were lower comparing with that of epsilon 3 allele carriers at baseline. 8 years later, TC and high density lipoprotein (HDL) elevated and LDL decreased with aging in this population (p < 0.01). The changes of TC levels were smaller in epsilon 2 allele carriers as compared to that of epsilon 3 allele carriers. The difference was still statistically significant after controlling for age, sex, smoking status, drinking habit, body mass index (BMI) and baseline TC level. The same trend of changes was noted for LDL between epsilon 2 and epsilon 3 allele carriers. However, no significant differences were noted between epsilon 4 and epsilon 3 allele carriers on lipid changes. This community-based study shows that epsilon 2 allele is helpful on lipid changes. The effect of epsilon 4 allele on lipid change is not strong in this elderly population. Genetic and environmental factors maybe co-operate on lipid metabolism in elderly persons. (c) 2012 Elsevier Ireland Ltd. All rights reserved.