PROBABLE INVIVO INDUCTION OF DIFFERENTIATION BY RETINOIC ACID OF PROMYELOCYTES IN ACUTE PROMYELOCYTIC LEUKEMIA
PROBABLE INVIVO INDUCTION OF DIFFERENTIATION BY RETINOIC ACID OF PROMYELOCYTES IN ACUTE PROMYELOCYTIC LEUKEMIA
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DOI：
10.1111/j.1365-2141.1984.tb02910.x
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发表时间：
1984-01-01
影响因子：
6.5
通讯作者：
NILSSON, B
中科院分区：
文献类型：
--
作者：
NILSSON, B
一名30岁的妇女在9月被诊断为急性早幼粒细胞白血病。1981.给予杜安霉素、阿糖胞苷、硫鸟嘌呤和泼尼松龙的化疗疗程，导致完全缓解。1982年1月复发。化疗没有导致第二次完全缓解;中性粒细胞减少症持续存在，骨髓粒细胞生成显著左移。在整个研究期间给予化疗疗程。在9月。1982年，骨髓早幼粒细胞显著增加，占有核细胞的51%。一个月后，情况没有变化;经口给予13-顺式-视黄酸（1 mg/kg）。骨髓早幼粒细胞比例逐渐下降至正常水平。维甲酸治疗20 wk后，外周血和骨髓仍正常。因此，维甲酸似乎已经诱导分化的异常增加，成熟缺陷的人口中的早幼粒细胞的急性早幼粒细胞白血病患者。
A 30-yr-old woman was diagnosed as having an acute promyelocytic leukemia in Sept. 1981. Chemotherapeutic courses of duanomycin, ara-C [cytosine arabinoside], thioguanine and prednisolone were administered, resulting in a complete remission. A relapse occurred in Jan. 1982. Chemotherapy did not lead to a 2nd complete remission; neutropenia persisted with a marked left shift of the marrow granulopoiesis. Courses of chemotherapy were given throughout the study. In Sept. 1982, marrow promyelocytes markedly increased, making up 51% of the nucleated cells. One month later the situation was unchanged; 13-cis-retinoic acid (1 mg/kg) was administered by mouth. Gradually the marrow proportion of promyelocytes decreased to normal levels. The peripheral blood and marrow were still normal after 20 wk of treatment with retinoic acid. Thus, retinoic acid seemed to have been inducing differentiation in an abnormally increased, maturation-deficient population of promyelocytes in a patient with acute promyelocytic leukaemia.