Apical amplification-a cellular mechanism of conscious perception?
Apical amplification-a cellular mechanism of conscious perception?
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DOI：
10.1093/nc/niab036
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发表时间：
2021
影响因子：
4.1
通讯作者：
Phillips WA
中科院分区：
文献类型：
--
作者：
Marvan T;Polák M;Bachmann T;Phillips WA
我们提出了一个理论观点的细胞基础的网络水平的过程中参与生产我们的意识体验。输入到第1层的一个大的新皮层细胞亚群的顶端突触的总和在其顶端干附近的整合区。这些输入来自不同的来源，并提供了一个上下文，在该上下文中，从感觉输入提取的信息传输到其基底和体周突触时，可以被放大。我们认为，顶端放大，使有意识的知觉经验，使其更灵活，从而更适应，是敏感的上下文。顶端放大为避免强循环的循环加工理论提供了一种可能的机制。它使全球神经元工作空间理论假设的广播可行，同时保留了接收广播的单个细胞的独特贡献。它还提供了有助于综合信息理论的整体方面的机制。由于顶端放大高度依赖于胆碱能、胺能和其他神经调质，它将意识体验的特定内容与整体精神状态和清醒时觉醒的波动联系起来。我们的结论是，顶端树突提供了一个上下文敏感的选择性放大，这是一个重要的先决条件有意识的知觉细胞机制。
We present a theoretical view of the cellular foundations for network-level processes involved in producing our conscious experience. Inputs to apical synapses in layer 1 of a large subset of neocortical cells are summed at an integration zone near the top of their apical trunk. These inputs come from diverse sources and provide a context within which the transmission of information abstracted from sensory input to their basal and perisomatic synapses can be amplified when relevant. We argue that apical amplification enables conscious perceptual experience and makes it more flexible, and thus more adaptive, by being sensitive to context. Apical amplification provides a possible mechanism for recurrent processing theory that avoids strong loops. It makes the broadcasting hypothesized by global neuronal workspace theories feasible while preserving the distinct contributions of the individual cells receiving the broadcast. It also provides mechanisms that contribute to the holistic aspects of integrated information theory. As apical amplification is highly dependent on cholinergic, aminergic, and other neuromodulators, it relates the specific contents of conscious experience to global mental states and to fluctuations in arousal when awake. We conclude that apical dendrites provide a cellular mechanism for the context-sensitive selective amplification that is a cardinal prerequisite of conscious perception.
影响因子：
3.5
作者：
Peel HJ;Sperandio I;Laycock R;Chouinard PA
通讯作者：
Chouinard PA