Genetic markers in alcoholic liver cirrhosis.
Genetic markers in alcoholic liver cirrhosis.
复制标题
酒精性肝硬化的遗传标记。
DOI：
10.1159/000154076
复制
发表时间：
1992
期刊：
影响因子：
1.8
通讯作者：
Á. Carracedo
中科院分区：
文献类型：
--
作者：
M. Lareu;A. Alvarez;C. Pardinas;L. Concheiro;Á. Carracedo
对157名酒精性肝硬化患者的11个遗传标记进行了分型，并与随机抽取的健康个体进行了比较。转铁蛋白、特异性组份、类粘蛋白、酯酶D、磷酸葡萄糖酸脱氢酶和腺苷酸激酶无显著差异。酒精性肝硬化与α 1-抗胰蛋白酶PI*Z等位基因、结合珠蛋白HP*1等位基因和酸性磷酸酶ACPAC表型密切相关。这些协会的生物学意义及其与酒精性肝硬化的发展关系也进行了讨论。
11 genetic markers were typed in 157 individuals suffering from alcoholic cirrhosis, and compared with a random sample of healthy individuals. No significant differences were found for transferrin, specific group component, orosomucoid, esterase D, phosphogluconate dehydrogenase and adenylate kinase. Strong associations between alcoholic cirrhosis and alpha-1-antitrypsin PI*Z allele, haptoglobin HP*1 allele and acid phosphatase ACP AC phenotype were observed. The biological significance of these associations and their relationships with the development of alcoholic cirrhosis are also discussed.