Evaluating effects of EPO in rodent behavioral assays related to depression.
Evaluating effects of EPO in rodent behavioral assays related to depression.
复制标题
评估 EPO 在与抑郁症相关的啮齿动物行为测定中的作用。
DOI：
10.1007/978-1-62703-308-4_8
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Newton,SamuelS
中科院分区：
文献类型：
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作者：
Duman,CatharineH;Newton,SamuelS
细胞因子促红细胞生成素（EPO）是造血的重要调节剂，具有众所周知的组织保护特性。神经营养作用在抑郁症的治疗中具有重要的机制，EPO的神经营养作用表明EPO样机制在抑郁症中的潜在治疗效用。对临床使用的抗抑郁药以及神经营养化合物有反应的啮齿动物行为模型可用于评估EPO和EPO样化合物的潜在抗抑郁特性。这里描述的啮齿动物模型是强迫游泳测试（FST），hyponeophagia测试和新物体识别测试。这些模型中的每一个都提供了不同的信息和抑郁症的相关性，每一个都可以用EPO和类似的化合物进行测试。
The cytokine erythropoietin (EPO) is an important regulator of hematopoesis and has well-known tissue protective properties. Neurotrophic action is implicated as mechanistically important in the treatment of depression, and neurotrophic actions of EPO suggest potential therapeutic utility of an EPO-like mechanism in depressive disorder. Rodent behavioral models that are responsive to clinically used antidepressants as well as to neurotrophic compounds can be used to assess potential antidepressant properties of EPO and EPO-like compounds. Rodent models described here are the forced-swim test (FST), a hyponeophagia test and the novel object recognition test. Each of these models provides different information and relevance to depression and each can be tested with EPO and similar compounds.