Effect of thiopentone on motor evoked potentials induced by transcranial magnetic stimulation in humans.
Effect of thiopentone on motor evoked potentials induced by transcranial magnetic stimulation in humans.
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硫喷妥钠对经颅磁刺激引起的人体运动诱发电位的影响。
DOI：
10.1093/bja/71.6.849
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发表时间：
1993
影响因子：
9.8
通讯作者：
Jun Karasawa
中科院分区：
文献类型：
--
作者：
Masahiko Kawaguchi;T. Sakamoto;K. Shimizu;Hideyuki Ohnishi;Jun Karasawa
我们研究了重复剂量硫喷妥钠对13例经颅磁刺激后运动诱发电位（MEP）的影响。静脉注射硫喷妥钠，初始剂量为2 mg kg-1，然后重复给药（每3分钟1 mg kg-1），直至EEG出现爆发抑制。给药的总剂量平均为10.7（SD 2.6）mg kg-1。磁线圈放置在MEP头皮刺激区，并记录对侧拇短展肌诱发的肌电反应。在初始剂量的硫喷妥钠后，在所有患者中记录到可重复的MEP反应，但振幅降低至基线值的42.8%。继续给予硫喷妥钠可使MEP记录成功率呈剂量依赖性降低，MEP波幅显著降低（P < 0.01）。潜伏期没有显着变化，但有增加的趋势。在爆发抑制的EEG，MEP没有成功地记录在所有患者。我们的结论是，MEP记录管理期间的硫喷妥钠是可行的，只有在最低剂量，MEP振幅显着减少。
We have studied the effect of repeated doses of thiopentone on motor evoked potentials (MEP) after transcranial magnetic stimulation in 13 patients. Thiopentone was administered i.v. in an initial dose of 2 mg kg-1, followed by repeated doses (1 mg kg-1 every 3 min) until the appearance of burst suppression on the EEG. The total dose administered was mean 10.7 (SD 2.6) mg kg-1. The magnetic coil was placed over the MEP scalp stimulation region and evoked electromyographic responses were recorded from the contralateral abductor pollicis brevis. After an initial dose of thiopentone, reproducible MEP responses were recorded in all patients, but amplitudes were reduced to 42.8% of baseline values. Further administration of repeated doses of thiopentone produced a dose-dependent decrease in success rate of MEP recordings and a significant reduction in MEP amplitude (P < 0.01). Latency did not change significantly, although there was a tendency to increase. During burst suppression on the EEG, MEP was not recorded successfully in all patients. We conclude that MEP recording during the administration of thiopentone is feasible only at a minimum dose, with a marked reduction in MEP amplitude.