Age‐related changes in the endocytic capacity of rat liver kupffer and endothelial cells
Age‐related changes in the endocytic capacity of rat liver kupffer and endothelial cells
复制标题
大鼠肝枯否细胞和内皮细胞内吞能力的年龄相关变化
作者：
A. Brouwer;R. Barelds;D. Knook
有许多迹象表明，网状内皮系统（RES）的功能能力随着年龄的增长而下降。本研究的目的是研究RES清除功能中年龄相关变化的细胞基础。实验主要集中在肝脏的枯否细胞和内皮细胞上，这些细胞是RES的主要组成部分，主要负责从循环中清除胶体物质。RES的清除能力在临床和实验上通过静脉注射胶体，如放射性标记的热聚集胶体白蛋白进行了测试。
There are many indications that the functional capacity of the reticuloendothelial system (RES) declines with age. The aim of this study was to investigate the cellular basis of age‐related changes in the clearance function of the RES. The experiments were focused mainly on Kupffer and endothelial cells of the liver which represent a major part of the RES and are primarily responsible for clearance of colloidal material from the circulation. The clearance capacity of the RES was tested clinically and experimentally by intravenous injection of colloids, such as radiolabeled heataggregated colloidal albumin.