Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex
Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex
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DOI：
10.1073/pnas.0403743101
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发表时间：
2004-09-07
影响因子：
11.1
通讯作者：
Matthews, PM
中科院分区：
文献类型：
--
作者：
Johansen-Berg, H;Behrens, TEJ;Matthews, PM
神经科学中的一个基本问题是结构和功能之间的关系。然而，粗略的地标并不能很好地对应于微结构边界，细胞结构也不能在用于功能研究的活脑中可视化。在这里，我们使用扩散加权和功能磁共振成像来直接检验结构-功能关系。不同的新皮质区域被定义为具有相似的连接性轮廓和识别出连接性改变的边界的体积。在没有使用先验信息的情况下，我们发现补充运动区(SMA)和SMA前运动区之间的边界发生了突然的轮廓变化。与此解剖学归属一致，推测的SMA和前SMA分别连接到运动区和前额叶区域。在仅使用连接性定义的体积和在设计为选择性地涉及SMA或前SMA的任务期间激活的体积之间发现了良好的空间相关性。这一发现证明了内侧额叶皮质结构和功能之间的强烈关系，并为测试大脑其他部位的这种对应关系提供了一种策略。
A fundamental issue in neuroscience is the relation between structure and function. However, gross landmarks do not correspond well to microstructural borders and cytoarchitecture cannot be visualized in a living brain used for functional studies. Here, we used diffusion-weighted and functional MRI to test structure-function relations directly. Distinct neocortical regions were defined as volumes having similar connectivity profiles and borders identified where connectivity changed. Without using prior information, we found an abrupt profile change where the border between supplementary motor area (SMA) and pre-SMA is expected. Consistent with this anatomical assignment, putative SMA and pre-SMA connected to motor and prefrontal regions, respectively. Excellent spatial correlations were found between volumes defined by using connectivity alone and volumes activated during tasks designed to involve SMA or pre-SMA selectively. This finding demonstrates a strong relationship between structure and function in medial frontal cortex and offers a strategy for testing such correspondences elsewhere in the brain.