INTERACTION OF HERPES-SIMPLEX VIRUS WITH CULTURES OF PERIPHERAL NERVOUS-TISSUE - ELECTRON-MICROSCOPIC STUDY
INTERACTION OF HERPES-SIMPLEX VIRUS WITH CULTURES OF PERIPHERAL NERVOUS-TISSUE - ELECTRON-MICROSCOPIC STUDY
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DOI：
10.1099/0022-1317-21-1-123
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发表时间：
1973-01-01
影响因子：
3.8
通讯作者：
FIELD, HJ
中科院分区：
文献类型：
--
作者：
HILL, TJ;FIELD, HJ
用单纯疱疹病毒1型和2型感染3日龄鸡胚背根神经节培养物。C.P.E.的证据。感染后14h光镜下可见。感染后每隔一段时间取出神经节，固定后切片作电子显微镜观察。病毒复制的所有阶段都在神经元中观察到，而很少有神经胶质细胞表现出感染的证据。似乎已经被感染的神经胶质细胞显示出病毒复制缺陷的迹象。这些发现的意义与单纯疱疹病毒感染潜伏期的机制有关。
Strains of herpes simplex virus types 1 and 2 were used to infect 3-day-old cultures of chick embryo dorsal root ganglia. Evidence of c.p.e. was seen by means of light microscopy at 14 h after infection. Ganglia were removed at intervals after infection and fixed and sectioned for electron microscopy. All stages of virus replication were observed in neurons, while few glial cells showed evidence of infection. Glial cells which did appear to have become infected showed signs of defective virus replication. The significance of the findings are discussed in relation to the mechanism of latency in herpes simplex virus infections.