The Role of Toll-Like Receptors in Retroviral Infection.
The Role of Toll-Like Receptors in Retroviral Infection.
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DOI：
10.3390/microorganisms8111787
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发表时间：
2020-11-14
期刊：
影响因子：
4.5
通讯作者：
Browne EP
中科院分区：
文献类型：
--
作者：
Browne EP
Toll-like receptors (TLRs) are key pathogen sensing receptors that respond to diverse microbial ligands, and trigger both innate and adaptive immune responses to infection. Since their discovery, a growing body of evidence has pointed to an important role for TLRs in retroviral infection and pathogenesis. These data suggest that multiple TLRs contribute to the anti-retroviral response, and that TLR engagement by retroviruses can have complex and divergent outcomes for infection. Despite this progress, numerous questions remain about the role of TLRs in retroviral infection. In this review, I summarize existing evidence for TLR-retrovirus interactions and the functional roles these receptors play in immunity and pathogenesis, with particular focus on human immunodeficiency virus (HIV).
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影响因子：
5.1
作者：
Bhargavan B;Kanmogne GD
通讯作者：
Kanmogne GD
影响因子：
6.7
作者：
Bosinger SE;Johnson ZP;Folkner KA;Patel N;Hashempour T;Jochems SP;Del Rio Estrada PM;Paiardini M;Lin R;Vanderford TH;Hiscott J;Silvestri G
通讯作者：
Silvestri G
DOI：
10.1097/qad.0b013e3283629117
发表时间：
2013-09-24
期刊：
AIDS (London, England)
影响因子：
--
作者：
Beima-Sofie KM;Bigham AW;Lingappa JR;Wamalwa D;Mackelprang RD;Bamshad MJ;Maleche-Obimbo E;Richardson BA;John-Stewart GC
通讯作者：
John-Stewart GC
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
15.9
作者：
Beignon, AS;McKenna, K;Bhardwaj, N
通讯作者：
Bhardwaj, N