Moderate-to-Severe Anaemia due to Afebrile Plasmodium falciparum Infection in Children aged 623 Months from the Rural District of Kongoussi, Burkina Faso
Moderate-to-Severe Anaemia due to Afebrile Plasmodium falciparum Infection in Children aged 623 Months from the Rural District of Kongoussi, Burkina Faso
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DOI：
10.1093/tropej/fmn049
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发表时间：
2008-12-01
影响因子：
2
通讯作者：
Donnen, Philippe
中科院分区：
文献类型：
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作者：
Ouedraogo, Hermann Z.;Zeba, Augustin;Donnen, Philippe
对456名623月龄农村儿童进行了一项以人群为基础的横断面研究，以探讨血红蛋白浓度和中重度贫血与恶性疟原虫(PF)感染的关系。采集毛细血管血，用HemoCue测定血红蛋白浓度，用血涂片镜检疟疾。在444名(97.4)儿童中发现了贫血，其中194名(42.5)为中到重度贫血。肺炎支原体感染240例(52.6%)，其中发热117例(25.6%)，发热123例(27.0%)。有发热和发热PF感染的儿童比无PF感染的儿童更容易发生中重度贫血，其优势比(95可信区间)分别为1.86(1.073.23)和2.4(1.294.48)，p 0.001。这些结果强调了这一人群中贫血和肺孢子虫感染的高负担。旨在控制疟疾贫血的战略，在疟疾病例治疗的基础上，应同时考虑发热性和无热性肺吸虫感染，以取得更好的效果。
A population-based cross-sectional study was conducted to investigate the association of haemoglobin concentration and moderate-to-severe anaemia with afebrile Plasmodium falciparum (PF) infection in 456 rural children aged 623 months. Capillary blood was obtained for haemoglobin concentration measurement by HemoCue and malaria detection by blood smear microscopy. Anaemia was noted in 444 (97.4) children with 194 (42.5) being moderate-to-severe anaemia. PF infection was noted in 240 (52.6) children with 117 (25.6) being afebrile and 123 (27.0) being febrile. Children with afebrile and those with febrile PF infection were more likely to have moderate-to-severe anaemia than children who were PF-free, with odds ratio (95 confidence interval) of 1.86 (1.073.23), p 0.028 and 2.40 (1.294.48), p 0.001, respectively. These results underline the high burden of both anaemia and PF infection in this population. Strategies aiming at controlling malarial anaemia and based on malaria case-treatment should consider both febrile and afebrile PF infection to allow for a better impact.