Decreased Cerebellar Fiber Density in Cortical Myoclonic Tremor but Not in Essential Tremor
Decreased Cerebellar Fiber Density in Cortical Myoclonic Tremor but Not in Essential Tremor
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DOI：
10.1007/s12311-012-0414-2
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发表时间：
2013-04-01
期刊：
影响因子：
3.5
通讯作者：
van Rootselaar, Anne-Fleur
中科院分区：
文献类型：
--
作者：
Buijink, Arthur W. G.;Caan, Matthan W. A.;van Rootselaar, Anne-Fleur
震颤产生的病理生理学在“家族性皮质肌阵挛性震颤伴癫痫”（FCMTE）和原发性震颤（ET）中仍不确定。在这两种疾病中，影像学和病理学研究表明小脑及其投射区受累。MR扩散张量成像允许估计白色物质组织组成，因此非常适合于量化体内结构变化。本研究旨在比较FCMTE和ET患者与健康对照者的小脑纤维密度。研究了7名FCMTE患者、8名ET患者和5名健康对照。小脑基于分数各向异性（FA）和平均扩散体积进行注释。计算平均小脑FA值以及平均小脑体积。组统计包括单因素方差分析和事后独立t检验。FCMTE组小脑区的平均FA为0.242（SD = 0.012），ET组为0.259（SD = 0.0115），对照组为0.262（SD = 0.0146）。FA存在显著的组效应（F（2）= 4.9，p = 0.02）。事后独立t检验显示，与对照组（t[10] = 2.5，p = 0.03）和ET患者（t[13] = 2.9，p = 0.01）相比，FCMTE患者的平均FA显著降低，而ET患者和对照组之间的平均FA没有差异（t[11] < 1.0）。这项研究表明，第一次在体内FCMTE小脑白色物质的显微结构损伤。这些结果确定了小脑在“皮质震颤”中的作用。
Pathophysiology of tremor generation remains uncertain in 'familial cortical myoclonic tremor with epilepsy' (FCMTE) and essential tremor (ET). In both disorders, imaging and pathological studies suggest involvement of the cerebellum and its projection areas. MR diffusion tensor imaging allows estimation of white matter tissue composition, and therefore is well suited to quantify structural changes in vivo. This study aimed to compare cerebellar fiber density between FCMTE and ET patients and healthy controls. Seven FCMTE patients, eight ET patients, and five healthy controls were studied. Cerebellum was annotated based on fractional anisotropy (FA) and mean diffusivity volumes. Mean cerebellar FA values were computed as well as mean cerebellar volume. Group statistics included one-way ANOVAs and post hoc independent t tests. Mean FA of the cerebellar region for FCMTE was 0.242 (SD = 0.012), for ET 0.259 (SD = 0.0115), and for controls 0.262 (SD = 0.0146). There was a significant group effect for FA (F(2) = 4.9, p = 0.02). No difference in mean cerebellar volume was found. Post hoc independent t tests revealed significantly decreased mean FA in FCMTE patients compared to controls (t[10] = 2.5, p = 0.03) and ET patients (t[13] = 2.9, p = 0.01), while there was no difference in mean FA between ET patients and controls (t[11] < 1.0). This study indicates for the first time microstructural damage of the cerebellar white matter in FCMTE in vivo. These results ascertain a role of the cerebellum in 'cortical tremor'.