Fruits and Vegetables Consumption and Risk of Stroke A Meta-Analysis of Prospective Cohort Studies
Fruits and Vegetables Consumption and Risk of Stroke A Meta-Analysis of Prospective Cohort Studies
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DOI：
10.1161/strokeaha.114.004836
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发表时间：
2014-06-01
期刊：
影响因子：
8.3
通讯作者：
Qu, Yan
中科院分区：
文献类型：
--
作者：
Hu, Dan;Huang, Junqian;Qu, Yan
背景和目的：我们进行了一项荟萃分析，以总结来自前瞻性队列研究的关于水果和蔬菜消费与卒中风险之间关系的证据。方法：通过检索Embase和PubMed数据库，检索到2014年1月的相关研究。采用随机效应模型对具有95%置信区间的研究特定相对风险进行汇总。用受限三次样条曲线评价剂量-反应关系。结果：纳入20项前瞻性队列研究，涉及760629名参与者的16981例卒中事件。总水果和蔬菜消费量最高和最低类别的卒中多变量相对危险度（95%置信区间）为0.79(0.75-0.84)，水果消费量为0.77(0.71-0.84)，蔬菜消费量为0.86（0.79-0.93）。亚组和元回归分析显示，总水果和蔬菜消费量与卒中风险呈负相关，在亚组分析中是一致的。柑橘类水果、苹果/梨和多叶蔬菜可能有助于保护。线性剂量-反应关系表明，每天每增加200克水果摄入量（非线性P =0.77）和蔬菜摄入量（非线性P =0.62），中风风险分别降低32%（0.68[0.56-0.82]）和11%（0.89[0.81-0.98]）。结论：水果和蔬菜的摄入量与中风的风险呈负相关。
Background and Purpose-We conducted a meta-analysis to summarize evidence from prospective cohort studies about the association of fruits and vegetables consumption with the risk of stroke.Methods-Pertinent studies were identified by a search of Embase and PubMed databases to January 2014. Study-specific relative risks with 95% confidence intervals were pooled using a random-effects model. Dose-response relationship was assessed by restricted cubic spline.Results-Twenty prospective cohort studies were included, involving 16 981 stroke events among 760 629 participants. The multivariable relative risk (95% confidence intervals) of stroke for the highest versus lowest category of total fruits and vegetables consumption was 0.79 (0.75-0.84), and the effect was 0.77 (0.71-0.84) for fruits consumption and 0.86 (0.79-0.93) for vegetables consumption. Subgroup and meta-regression showed that the inverse association of total fruits and vegetables consumption with the risk of stroke was consistent in subgroup analysis. Citrus fruits, apples/pears, and leafy vegetables might contribute to the protection. The linear dose-response relationship showed that the risk of stroke decreased by 32% (0.68 [0.56-0.82]) and 11% (0.89 [0.81-0.98]) for every 200 g per day increment in fruits consumption (P for nonlinearity=0.77) and vegetables consumption (P for nonlinearity=0.62), respectively.Conclusions-Fruits and vegetables consumption are inversely associated with the risk of stroke.