[Relapse of peptic ulcer after quick healing induced by proton pump inhibitors].
[Relapse of peptic ulcer after quick healing induced by proton pump inhibitors].
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质子泵抑制剂快速愈合后消化性溃疡复发[J].
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
T. Arisawa
中科院分区：
文献类型：
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作者：
Y. Tsukamoto;Y. Niwa;T. Arisawa
用质子泵抑制剂治疗的消化性溃疡比用组胺H2受体拮抗剂治疗的溃疡愈合得更快。虽然在消化性溃疡的医学治疗中令人满意的愈合而不复发是可取的，但质子泵抑制剂治疗后的复发率尚未得到充分的研究。到目前为止，有几篇报道表明，奥美拉唑治疗的消化性溃疡的复发率低于H2拮抗剂治疗的溃疡。我们对醋酸性胃溃疡肉芽组织血管生成、胃黏膜胶原合成等实验研究表明，H2拮抗剂对伤口愈合有抑制作用，而质子泵抑制剂则没有。因此，质子泵抑制剂可能至少对消化性溃疡的自然史没有不良影响。
Peptic ulcers treated with a proton pump inhibitor heal more quickly than those treated with a histamine H2 receptor antagonist. Although satisfactory healing without relapse is desirable in the medical treatment of peptic ulcers, the relapse rate after treatment with proton pump inhibitors has not been sufficiently studied. Up to now, several reports have suggested that peptic ulcers treated with omeprazole recur less frequently than those treated with H2 antagonists. Our experimental studies on angiogenesis in granulation tissue of acetic acid-induced gastric ulcers, gastric mucosal collagen synthesis etc., show that H2 antagonists have an inhibitory effect on wound healing, but that proton pump inhibitors do not. It is suggested, therefore, that proton pump inhibitors may at least have no undesirable effect on the natural history of peptic ulcer.