Colorectal cancer: prevention and management of metastatic disease.
Colorectal cancer: prevention and management of metastatic disease.
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DOI：
10.1155/2014/782890
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发表时间：
2014
影响因子：
--
通讯作者：
Sugarbaker PH
中科院分区：
文献类型：
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作者：
Sugarbaker PH
本文比较了两种最常见的结直肠癌转移类型的异同。对肝转移的手术联合全身化疗的治疗进行了阐述。强调了肝转移与腹膜转移不同的自然病程，以及预防腹膜转移的可能性。围手术期癌症化疗或二次手术必须考虑作为个体化治疗的选择患者有小体积腹膜转移或谁是已知的在腹膜表面的后续疾病进展的风险。然而，当结直肠癌患者在随访中确诊腹膜转移时，采用减法手术和围手术期高温化疗联合治疗是可以治愈的，这一事实不容忽视。对进展性结直肠癌患者进行仔细的随访和及时的干预是多学科团队推荐的管理策略的必要组成部分。在对目前可用的数据进行关键评估后，这些预防和管理结直肠癌转移的策略作为作者的高标准护理建议提出。随着获得的信息越来越多，可能需要进行修改。
This paper compared the similarities and differences of the two most common types of colorectal cancer metastases. The treatment of liver metastases by surgery combined with systemic chemotherapy was explained. The different natural history of liver metastases as compared to peritoneal metastases and the possibility for prevention of peritoneal metastases were emphasized. Perioperative cancer chemotherapy or second-look surgery must be considered as individualized treatments of selected patients who have small volume peritoneal metastases or who are known to be at risk for subsequent disease progression on peritoneal surfaces. However, the fact that peritoneal metastases, when diagnosed in the follow-up of colorectal cancer patients, can be cured with a combination of cytoreductive surgery and hyperthermic perioperative chemotherapy cannot be ignored. Careful follow-up and timely intervention in colorectal cancer patients with progressive disease are a necessary part of the management strategies recommended by the multidisciplinary team. After a critical evaluation of the data currently available, these strategies for prevention and management of colorectal metastases are presented as the author's recommendations for a high standard of care. As more information becomes available, modifications may be necessary.