GABA levels are decreased after stroke and GABA changes during rehabilitation correlate with motor improvement.
GABA levels are decreased after stroke and GABA changes during rehabilitation correlate with motor improvement.
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DOI：
10.1177/1545968314543652
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发表时间：
2015-03
影响因子：
4.2
通讯作者：
Ho YC
中科院分区：
文献类型：
--
作者：
Blicher JU;Near J;Næss-Schmidt E;Stagg CJ;Johansen-Berg H;Nielsen JF;Østergaard L;Ho YC
γ-氨基丁酸（GABA）是大脑中主要的抑制性神经递质，在运动学习中起重要作用。我们的目的是测量脑卒中后初级运动皮层中的GABA含量（使用GABA编辑的磁共振波谱[MRS]），以及在2周的强制性诱导运动治疗（CIMT）期间与运动恢复的关系。招募了21名患者（卒中后3-12个月）和20名健康受试者。在基线和CIMT后进行磁共振成像结构T1和GABA编辑的MRS，并在健康受试者中进行一次。通过GABA编辑的MRS测量GABA：肌酸（GABA：Cr）比率。使用Wolf运动功能测试（WMFT）测量运动功能。卒中患者（n = 19）和健康受试者之间的基线比较显示，即使校正体素中的灰质含量（P <0.01）和当表达GABA相对于N-乙酰天冬氨酸（NAA; P = 0.03）时，卒中患者的GABA：Cr比值也显著较低（P <0.001）。CIMT治疗2周后，患者的WMFT显著改善，但未观察到GABA：Cr比值（n = 17）的一致变化。然而，WMFT的改善程度与GABA：Cr变化的幅度显著相关（P <0.01），GABA：Cr比值的降低与运动功能的改善相关。在中风后3至12个月的患者中，初级运动皮层中的GABA水平低于健康受试者。GABA和恢复之间的关系值得进一步研究GABA MRS作为中风后恢复的生物标志物的潜在用途。
γ-Aminobutyric acid (GABA) is the dominant inhibitory neurotransmitter in the brain and is important in motor learning. We aimed to measure GABA content in primary motor cortex poststroke (using GABA-edited magnetic resonance spectroscopy [MRS]) and in relation to motor recovery during 2 weeks of constraint-induced movement therapy (CIMT). Twenty-one patients (3-12 months poststroke) and 20 healthy subjects were recruited. Magnetic resonance imaging structural T1 and GABA-edited MRS were performed at baseline and after CIMT, and once in healthy subjects. GABA:creatine (GABA:Cr) ratio was measured by GABA-edited MRS. Motor function was measured using Wolf Motor Function Test (WMFT). Baseline comparison between stroke patients (n = 19) and healthy subjects showed a significantly lower GABA:Cr ratio in stroke patients (P < .001) even after correcting for gray matter content in the voxel (P < .01) and when expressing GABA relative to N-acetylaspartic acid (NAA; P = .03). After 2 weeks of CIMT patients improved significantly on WMFT, but no consistent change across the group was observed for the GABA:Cr ratio (n = 17). However, the extent of improvement on WMFT correlated significantly with the magnitude of GABA:Cr changes (P < .01), with decreases in GABA:Cr ratio being associated with better improvements in motor function. In patients 3 to 12 months poststroke, GABA levels are lower in the primary motor cortex than in healthy subjects. The observed association between GABA and recovery warrants further studies on the potential use of GABA MRS as a biomarker in poststroke recovery.