A single bout of high-intensity aerobic exercise facilitates response to paired associative stimulation and promotes sequence-specific implicit motor learning
A single bout of high-intensity aerobic exercise facilitates response to paired associative stimulation and promotes sequence-specific implicit motor learning
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DOI：
10.1152/japplphysiol.00498.2014
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发表时间：
2014-12-01
影响因子：
3.3
通讯作者：
Boyd, Lara A.
中科院分区：
文献类型：
--
作者：
Mang, Cameron S.;Snow, Nicholas J.;Boyd, Lara A.
本研究的目的是评估单次高强度有氧运动对1)通过配对联想刺激（PAS）反应的长期增强（LTP）样神经可塑性和2)序列特异性内隐运动学习的时间和空间成分的影响。此外，还评估了运动诱导的全身性脑源性神经营养因子（BDNF）的增加与PAS反应和运动学习之间的关系。16名年轻健康参与者完成了六个实验阶段，包括：1)休息后进行PAS；2)有氧运动加PAS；3)休息后进行连续跟踪（CT）任务练习和4)无运动24小时记忆保留测试；5)有氧运动后进行CT任务练习，6)无运动24小时潴留试验。CT任务包括一个嵌入的重复序列，允许评估特定序列的内隐学习。经颅磁刺激产生的运动诱发电位恢复曲线斜率，经颅磁刺激前进行有氧运动比静息时增加更大（增加59.8%，增加14.2%,P = 0.02）。在有氧运动条件下，重复序列上的CT任务表现的滞后时间从练习早期（-100.8 ms）到练习后期（-75.2 ms, P < 0.001）有所改善，并维持在保持状态（-79.2 ms, P = 0.004），但在休息条件下没有变化（P < 0.16）。有氧运动后，全身BDNF平均增加3.4倍（P = 0.003），但这种变化与神经生理或行为测量无关（P = 0.42）。这些结果表明，单次高强度有氧运动可以启动ltp样神经可塑性，促进序列特异性内隐运动学习。
The objectives of the present study were to evaluate the impact of a single bout of high-intensity aerobic exercise on 1) long-term potentiation (LTP)-like neuroplasticity via response to paired associative stimulation (PAS) and 2) the temporal and spatial components of sequence-specific implicit motor learning. Additionally, relationships between exercise-induced increases in systemic brain-derived neurotrophic factor (BDNF) and response to PAS and motor learning were evaluated. Sixteen young healthy participants completed six experimental sessions, including the following: 1) rest followed by PAS; 2) aerobic exercise followed by PAS; 3) rest followed by practice of a continuous tracking (CT) task and 4) a no-exercise 24-h retention test; and 5) aerobic exercise followed by CT task practice and 6) a no-exercise 24-h retention test. The CT task included an embedded repeated sequence allowing for evaluation of sequence-specific implicit learning. Slope of motor-evoked potential recruitment curves generated with transcranial magnetic stimulation showed larger increases when PAS was preceded by aerobic exercise (59.8% increase) compared with rest (14.2% increase, P = 0.02). Time lag of CT task performance on the repeated sequence improved under the aerobic exercise condition from early (-100.8 ms) to late practice (-75.2 ms, P < 0.001) and was maintained at retention (-79.2 ms, P = 0.004) but did not change under the rest condition (P > 0.16). Systemic BDNF increased on average by 3.4-fold following aerobic exercise (P = 0.003), but the changes did not relate to neurophysiological or behavioral measures (P > 0.42). These results indicate that a single bout of high-intensity aerobic exercise can prime LTP-like neuroplasticity and promote sequence-specific implicit motor learning.