Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation
Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation
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DOI：
10.1016/s0304-3940(00)00798-9
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发表时间：
2000-02-25
影响因子：
2.5
通讯作者：
Müller-Gärtner, HW
中科院分区：
文献类型：
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作者：
Mottaghy, FM;Krause, BJ;Müller-Gärtner, HW
研究了重复经颅磁刺激(RTMS)对正电子发射断层扫描(PET)显示的局部脑血流量(RCBF)变化的影响，同时研究了受试者进行2-back文字工作记忆(WM)任务。右侧或左侧背外侧前额叶皮质(DLPFC)的rTMS，而不是额叶中线皮质的rTMS，显著降低了WM任务的成绩，同时导致刺激部位和远处脑区的rCBF显著减少。这些结果首次证明了rTMS在神经元网络元素中产生暂时性功能损害的能力，从而改变其分布的激活并导致行为后果。(C)2000由爱思唯尔科学爱尔兰有限公司出版。保留所有权利。
We studied the effect of repetitive transcranial magnetic stimulation (rTMS) on changes in regional cerebral blood flow (rCBF) as revealed by positron emission tomography (PET) while subjects performed a 2-back verbal working memory (WM) task. rTMS to the right or left dorsolateral prefrontal cortex (DLPFC), but not to the midline frontal cortex, significantly worsened performance in the WM task while inducing significant reductions in rCBF at the stimulation site and in distant brain regions. These results for the first time demonstrate the ability of rTMS to produce temporary functional lesions in elements of a neuronal network thus changing its distributed activations and resulting in behavioral consequences. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.