pH and near-infrared active; chitosan-coated halloysite nanotubes loaded with curcumin-Au hybrid nanoparticles for cancer drug delivery
pH and near-infrared active; chitosan-coated halloysite nanotubes loaded with curcumin-Au hybrid nanoparticles for cancer drug delivery
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DOI：
10.1016/j.ijbiomac.2018.01.163
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发表时间：
2018-06-01
影响因子：
8.2
通讯作者：
Han, Sung Soo
中科院分区：
文献类型：
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作者：
Rao, Kummara Madhusudana;Kumar, Anuj;Han, Sung Soo
在这项工作中，我们提出了一种生物友好的原位制备方法，以姜黄素（CUR）作为抗癌药物，然后用生物粘合剂壳聚糖（CS）作为多糖，在管腔和生物相容性高石纳米管（HNTs）的表面笼中制备金纳米管（六边形和棒状结构）。利用FTIR、XRD、XPS、STEM等技术对HNTs中Au NPs的形成及其与CUR和CS的相互作用进行了表征。有趣的是，金纳米粒子在760和980 nm处显示出纵向等离子体共振带，这表明了杂化纳米粒子的近红外响应特性。TEM图像证实了金纳米粒子的棒状和六边形结构。结果表明，CUR的加载效率可达12%。重要的是，在酸性条件下（pH 5.5）比碱性条件下（pH 7.4）释放更多的CUR。研究了HNT杂化纳米颗粒对MCF-7癌细胞的抗癌潜力，发现在细胞内肿瘤细胞环境（pH 5.5）下比在细胞外环境（pH 7.4）下表现出更有效的抗癌活性。此外，所开发的由Au NPs（近红外响应特性）和ph响应的CUR释放组成的HNT杂交纳米颗粒可以使其适合于具有近红外成像的癌细胞靶向药物递送平台。(C) 2018 Elsevier B.V.版权所有
In this work, we propose biofriendly in-situ preparation method of Au NPs (hexagonal and rod-shape structures) in the lumen as well as the surface cage of biocompatible halloysite nanotubes (HNTs) using curcumin (CUR) as anticancer drug and subsequently coating with bio-adhesive chitosan (CS) as a polysaccharide. The formation of Au NPs and their interactions with CUR and CS exist in the HNTs has been characterized by FTIR, XRD, XPS, STEM techniques. Interestingly, Au NPs showed longitudinal plasmon resonance bands at 760 and 980 nm that indicate the near-infrared (NIR) responsive property of hybrid nanopartides. Rod shape and hexagonal structures of Au NPs were produced as confirmed by TEM images. The loading efficiency of CUR was found as much as 12%. Importantly, more CUR release was achieved under acidic conditions (pH 5.5) than basic conditions (pH 7.4). The anticancer potential of HNT hybrid nanoparticles on MCF-7 cancer cells was studied and showed efficient anticancer activity under intracellular tumor cell environment (pH 5.5) than extracellular conditions (pH 7.4). Moreover, the developed HNT hybrid nanoparticles consisting of Au NPs (NIR responsive property) and pH-responsive CUR release could make it suitable for cancer cell-targeted drug delivery platform with NIR-imaging. (C) 2018 Elsevier B.V. All rights reserved.