Stabilization of Microbial Communities by Responsive Phenotypic Switching
Stabilization of Microbial Communities by Responsive Phenotypic Switching
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DOI：
10.1101/2021.12.12.472272
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发表时间：
2021-12
期刊：
影响因子：
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通讯作者：
P. A. Haas;M. A. Gutierrez;N. Oliveira;R. Goldstein
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文献类型：
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作者：
P. A. Haas;M. A. Gutierrez;N. Oliveira;R. Goldstein
克隆微生物可以在不同的表型之间切换，最近的理论工作表明，这些亚群之间的随机切换可以稳定微生物群落。然而，这种表型转换不一定是随机的，但也可以对生物和非生物的环境因素做出反应。在这里，受细菌持久性表型的激励，我们通过分析对竞争物种的表型转换来探索这种响应转换的生态效应。结果表明，具有响应性切换的微生物群落的稳定性不同于仅具有随机切换的微生物群落的稳定性。为了理解响应性转换稳定共存的机制，我们继续分析简单的两物种模型。结合精确结果和数值模拟，我们将经典的无表型变异的两个物种竞争的稳定性结果推广到一个物种在两个表型之间随机和响应地切换的情况。特别地，我们证明了在随机切换本身不影响群落的稳定性的情况下，响应切换能够稳定共存。
Clonal microbes can switch between different phenotypes and recent theoretical work has shown that stochastic switching between these subpopulations can stabilize microbial communities. This phenotypic switching need not be stochastic, however, but could also be in response to environmental factors, both biotic and abiotic. Here, motivated by the bacterial persistence phenotype, we explore the ecological effects of such responsive switching by analyzing phenotypic switching in response to competing species. We show that the stability of microbial communities with responsive switching differs generically from that of communities with stochastic switching only. To understand the mechanisms by which responsive switching stabilizes coexistence, we go on to analyze simple two-species models. Combining exact results and numerical simulations, we extend the classical stability results for the competition of two species without phenotypic variation to the case in which one species switches, stochastically and responsively, between two phenotypes. In particular, we show that responsive switching can stabilize coexistence even when stochastic switching on its own does not affect the stability of the community.